Results
| PMID | 25984730 |
| Gene Name | VEGFA |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | VEGF (-460 C/T, +405 G/C, and +936 C/T) |
| Population size | 255 |
| Population details | 255 (105 women with endometriosis, 150 women with no laparoscopic evidence of disease) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Syst Biol Reprod Med. 2015;61(4):238-44. doi: 10.3109/19396368.2015.1041622. Epub Henidi, Belkis| Kaabachi, Wajih| Naouali, Abir| Kaabachi, Safa| Zhioua, Amel| Haj Sassi, Faycal| Hamzaoui, Kamel Department of Basic Sciences, Division of Histology and Immunology, Medicine School of Tunis, Tunis El Manar University , Unit Research UR12SP15 and. The vascular endothelial growth factor (VEGF), a major angiogenic factor, is known to play an important role in the development of endometriosis. The aim of this study was to investigate the association of three VEGF (-460 C/T, +405 G/C, and +936 C/T) polymorphisms with the risk of endometriosis in the Tunisian population. This study includes 105 women with endometriosis and 150 women with no laparoscopic evidence of disease. Genotyping of the VEGF -460 C/T, +405 G/C, and +936 C/T polymorphisms were performed by polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP). The distribution of genotypes (P = 0.006) and allele (P = 0.0009) frequencies of the +936 C/T polymorphism was significantly different between patients and controls. Patients with stages III-IV endometriosis showed a higher VEGF + 936T allele frequency than controls (P = 0.0001). However, the distribution of genotypes and allele frequencies of the VEGF -460 C/T and +405 G/C polymorphisms did not differ significantly between endometriosis patients and controls. These findings suggest that the VEGF +936 C/T polymorphism may be a risk factor for endometriosis development and the VEGF +936 T allele is associated with an increased risk of stages III-IV endometriosis in the Tunisian population. Mesh Terms: Case-Control Studies| Endometriosis/*genetics| Female| Gene Frequency| *Genetic Predisposition to Disease| Haplotypes| Humans| *Polymorphism, Genetic| Tunisia| Vascular Endothelial Growth Factor A/*genetics|DA 2016/04/12 06:00 |
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