| Pathways | Gene |
|---|
| ABC transporters | ABCC4, CFTR, ABCB1, ABCG2 |
| Acute myeloid leukemia | STAT5A, PIK3CA, PIM2, EIF4EBP1, AKT1, FLT3, MTOR, KIT, KRAS, MYC, NFKB1, NRAS, PIK3CA, PIK3R1, MAPK1, CCND1, RELA, BRAF, STAT3 |
| Adherens junction | CTNNA1, CTNNB1, EGFR, ERBB2, FGFR1, FYN, NECTIN3, IGF1R, INSR, SMAD3, SMAD4, MET, ACP1, MAPK1, NECTIN1, ACTB, SRC, MAP3K7, ACTN4, NECTIN4, CDH1, RHOA, CDC42, SNAI1, RAC1 |
| Adipocytokine signaling pathway | MAPK8, JAK2, AKT1, MTOR, LEP, LEPR, NFKB1, PPARA, RELA, STAT3, TNF, TNFRSF1A, TNFRSF1B, IRS2, SOCS3, ADIPOQ, CD36, ADIPOR2, ADIPOR1, NPY |
| Adrenaline and noradrenaline biosynthesis | COMT, COMT |
| Adrenergic signaling in cardiomyocytes | CREB1, AGTR1, AGTR2, AKT1, PLCB1, ATP1B4, PLCB3, MAPK1, BCL2, TPM3, CREB3L1, ATF2 |
| African trypanosomiasis | F2RL1, PLCB1, APOA1, ICAM1, IFNG, FAS, IL1B, FASLG, IL6, IL10, IL12A, IL18, IDO1, PLCB3, TLR9, SELE, TNF, VCAM1 |
| AGE-RAGE signaling pathway in diabetic complications | CDKN1B, COL4A2, AGER, AGTR1, EDN1, EGR1, AKT1, F3, VEGFD, FOXO1, PLCB1, FN1, ICAM1, IL1A, IL1B, IL6, CXCL8, JUN, KRAS, SMAD3, SMAD4, MMP2, NFKB1, NOS3, NRAS, SERPINE1, PIK3CA, PIK3R1, PLCB3, PLCD1, MAPK1, BAX, CCND1, BCL2, RELA, CCL2, SELE, STAT3, TGFB1, TGFB2, TNF, VCAM1, VEGFA, VEGFC, CASP3, STAT5A, MAPK8, JAK2, PIK3CA, CDC42, RAC1, COL4A1 |
| Alanine, aspartate and glutamate metabolism | FOLH1 |
| Alcoholism | CREB1, HIST2H3C, CRH, DRD2, H2AFX, HDAC1, HDAC2, KRAS, MAOA, NRAS, NTRK2, MAPK1, BDNF, SHC1, BRAF, HIST3H3, CREB3L1, NPY, ATF2 |
| Aldosterone | INS, PIK3CA, ATP1B4, HSD11B2, IGF1, INSR, KRAS, PIK3CA, PIK3R1, MAPK1, SGK1 |
| Aldosterone synthesis and secretion | CREB1, CREB3L1, CYP11A1, AGTR1, PLCB1, HSD3B2, PLCB3, STAR, SCARB1, ATF2 |
| Allograft rejection | CD40, HLA-DRA, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DRB1, HLA-E, HLA-G, IFNG, FAS, IL2, FASLG, IL4, IL5, IL10, IL12A, TNF, CD40, CD40LG, CD40LG |
| alpha-Linolenic acid metabolism | PLA2G16, PLA2G2A, PLA2G4A |
| Alzheimer disease-presenilin pathway | CD44, CD44 |
| Alzheimer's disease | PLCB1, GSK3B, APOE, FAS, IL1B, MME, COX2, NDUFS1, ATP5A1, PLCB3, MAPK1, ADAM17, TNF, TNFRSF1A, CASP3, ATP5F1B |
| Amino sugar and nucleotide sugar metabolism | GALT, PGM1 |
| Amoebiasis | COL4A2, CTSG, PLCB1, FN1, LAMA1, CXCL1, HSPB1, IFNG, IL1B, IL1R1, IL6, CXCL8, IL10, IL12A, ITGB2, ARG2, LAMA5, LAMC2, MUC2, NFKB1, NOS2, PIK3CA, PIK3R1, PLCB3, PTK2, RELA, TGFB1, TGFB2, TLR2, TLR4, TNF, IL1R2, ACTN4, CASP3, PIK3CA, LAMC1, COL4A1 |
| Amphetamine addiction | CREB1, CREB3L1, SIRT1, FOS, HDAC1, JUN, MAOA, ATF2 |
| AMPK signaling pathway | CFTR, EIF4EBP1, ELAVL1, AKT1, FOXO1, SIRT1, MTOR, IGF1, IGF1R, INSR, LEP, LEPR, PIK3CA, PIK3R1, PPARG, CCND1, MAP3K7, CAB39L, IRS2, ADIPOQ, CD36, INS, CREB1, CREB3L1, ADIPOR2, PIK3CA, ADIPOR1 |
| Amyotrophic lateral sclerosis | GPX1, BAX, BCL2, BCL2L1, SOD1, TNF, TNFRSF1A, TNFRSF1B, TP53, CASP1, CASP3, CAT, RAC1 |
| Angiogenesis | Grb14 |
| Angiogenesis | STAT3, STAT3, STAT3, STAT3, STAT3, STAT3 |
| Angiogenesis | Crk, Crk, CRK |
| Angiogenesis | Crk, Crk |
| Angiogenesis | TF, TF |
| Angiogenesis | JAK1, Jak1, JAK1, Jak1 |
| Antifolate resistance | ABCC4, FOLR1, IL1B, IL6, MTHFR, NFKB1, RELA, TNF, ABCG2 |
| Antigen processing and presentation | CTSB, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DRB1, HLA-E, HLA-G, HSPA4, HSPA6, HSP90AA1, IFNG, KIR2DL1, KIR2DL3, KIR2DS4, KIR3DL1, TNF, CD4, CD74, CREB1, HLA-DRA, KLRD1, KLRC1, KIR2DS5 |
| Apelin signaling pathway | JAG1, AGTR1, EGR1, AKT1, PLCB1, GABARAPL1, MTOR, KRAS, SMAD3, SMAD4, NOS2, NOS3, NRAS, SERPINE1, PLAT, PLCB3, MAPK1, CCND1, SPP1, CDH1 |
| Apoptosis | BCL2L11, CSF2RB, CTSB, CTSD, AKT1, FOS, BIRC5, FAS, FASLG, JUN, KRAS, MCL1, ATM, NFKB1, NGF, NRAS, PIK3CA, PIK3R1, MAPK1, BAX, BCL2, RELA, BCL2L1, ACTB, TNF, TNFRSF1A, TP53, CASP3, TNFSF10, MAPK8, PIK3CA |
| Apoptosis | MAPK8, BCL2L11, BIRC5, BAX, BCL2, BCL2L1, TNFRSF1A, CASP3 |
| Apoptosis signaling pathway | TNF |
| Apoptosis signaling pathway | TNF |
| Apoptosis signaling pathway | TNF |
| Arachidonic acid metabolism | PLA2G16, CYP2B6, CYP2C19, CYP2E1, ALOX15, GPX1, GPX3, PLA2G2A, PLA2G4A, PTGDS, PTGS1, PTGS2, PTGES2, AKR1C3, PTGES |
| Arginine and proline metabolism | ALDH3A2, ARG2, MAOA, NOS2, NOS3 |
| Arginine biosynthesis | ARG2, NOS2, NOS3 |
| Arrhythmogenic right ventricular cardiomyopathy | CTNNA1, CTNNB1, GJA1, ITGA6, ITGA2, ITGA3, ITGAV, ITGB1, ITGB3, ITGB5, ITGB6, ACTB |
| Ascorbate and aldarate metabolism | ALDH3A2 |
| Asthma | CD40, HLA-DRA, CCL11, FCER1G, HLA-DPB1, HLA-DQA1, HLA-DRB1, IL4, IL5, IL10, IL13, TNF, CD40, CD40LG, CD40LG |
| Autoimmune thyroid disease | CD40, HLA-DRA, CGA, CTLA4, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DRB1, HLA-E, HLA-G, FAS, IL2, FASLG, IL4, IL5, IL10, CD40, CD40LG, CD40LG |
| Autophagy | MAPK8, INS, CTSB, CTSD, AKT1, GABARAPL1, MTOR, HIF1A, HMGB1, IGF1R, KRAS, NRAS, PIK3CA, PIK3R1, MAPK1, PTEN, BCL2, BCL2L1, MAP3K7, IRS2, PIK3CA, DAPK1 |
| Autophagy - other | GABARAPL1, MTOR |
| Axon guidance | PAK4, SEMA3A, CFL1, DPYSL2, EFNA1, FYN, GSK3B, ITGB1, KRAS, L1CAM, LIMK1, MET, NRAS, PAK1, PIK3CA, PIK3R1, WNT4, MAPK1, PTK2, NTN4, CXCL12, BMPR1B, SRC, WNT5A, CXCR4, NRP1, PIK3CA, RHOA, CDC42, RAC1, SEMA3C |
| Axon guidance mediated by semaphorins | Sema3A |
| Axon guidance mediated by Slit/Robo | Cxcr4, Cxcr4 |
| B cell receptor signaling pathway | AKT1, FOS, GSK3B, JUN, KRAS, NFKB1, NRAS, PIK3CA, PIK3R1, MAPK1, RELA, CD79A, PIK3CA, RAC1 |
| Bacterial invasion of epithelial cells | PIK3CA, RHOA, 09-Sep, CRK, CTNNA1, CTNNB1, FN1, ITGB1, MET, PIK3CA, PIK3R1, PTK2, ACTB, SHC1, SRC, CDH1, CDC42, RAC1 |
| Basal cell carcinoma | CTNNB1, GSK3B, WNT4, BMP4, TP53, WNT1, WNT2, WNT5A, WNT7A |
| Basal transcription factors | TBPL2 |
| Base excision repair | OGG1, HMGB1, APEX1, PCNA, XRCC1 |
| beta-Alanine metabolism | ALDH3A2 |
| Bile secretion | ABCC4, CFTR, EPHX1, ATP1B4, AQP8, ABCB1, CA2, NR0B2, ABCG2, SCARB1 |
| Biosynthesis of amino acids | ENO1, ENO2, ARG2, MAT2A |
| Bladder cancer | CDKN1A, CDKN2A, TYMP, EGF, EGFR, ERBB2, CXCL8, KRAS, MMP1, MMP2, MMP9, MYC, NRAS, MAPK1, RB1, CCND1, SRC, BRAF, THBS1, TP53, VEGFA, CDH1, DAPK1 |
| Breast cancer | CDKN1A, CTNNB1, JAG1, EGF, EGFR, ERBB2, AKT1, ESR1, ESR2, FGF1, FGF2, FGFR1, FLT4, HEY1, FOS, MTOR, GSK3B, IGF1, IGF1R, JUN, KIT, KRAS, HES5, MYC, NFKB2, NOTCH1, NOTCH4, NRAS, PGR, PIK3CA, PIK3R1, WNT4, DLL4, MAPK1, PTEN, RB1, CCND1, SHC1, BRCA1, BRAF, BRCA2, TP53, WNT1, WNT2, WNT5A, WNT7A, PIK3CA |
| C-type lectin receptor signaling pathway | MAPK8, PIK3CA, RHOA |
| Cadherin signaling pathway | EGFR, EGFR |
| Cadherin signaling pathway | EGFR, EGFR, EGFR, EGFR |
| Cadherin signaling pathway | EGFR, EGFR, EGFR, EGFR, EGFR, EGFR |
| Cadherin signaling pathway | Fyn, Fyn |
| Caffeine metabolism | NAT2, CYP1A2, CYP2A6, XDH |
| Calcium signaling pathway | AGTR1, EDNRA, EGFR, ERBB2, ERBB3, F2R, PLCB1, LHCGR, NOS2, NOS3, OXTR, PDGFRA, PLCB3, PLCD1, PTGER3, PTGFR, TACR2, TACR1, P2RX3 |
| cAMP signaling pathway | ABCC4, CFTR, DRD2, EDNRA, AKT1, F2R, ATP1B4, FOS, FSHB, FSHR, AMH, JUN, NFKB1, OXTR, PAK1, GHRL, PIK3CA, PIK3R1, PPARA, MAPK1, PTGER2, PTGER3, RELA, BDNF, BRAF, SSTR1, SSTR5, MAPK8, CREB1, CREB3L1, PIK3CA, NPY, RHOA, RAC1 |
| Carbohydrate digestion and absorption | PIK3CA, AKT1, ATP1B4, AMY2A, PIK3CA, PIK3R1 |
| Carbon metabolism | ENO1, ENO2, MTHFR, CAT |
| Cardiac muscle contraction | ATP1B4, COX2, TPM3 |
| CCKR signaling map | ITGB1, ITGB1, ITGB1 |
| CCKR signaling map | CCND1, CCND1, CCND1, CCND1, CCND1, CCND1, CCND1, CCND1 |
| CCKR signaling map | CXCL2, CXCL2 |
| CCKR signaling map | CXCL1, CXCL1 |
| CCKR signaling map | MMP7, MMP7, MMP7, MMP7 |
| CCKR signaling map | MMP3 |
| CCKR signaling map | MMP9, MMP9 |
| CCKR signaling map | SHC1, SHC1 |
| CCKR signaling map | CETP |
| CCKR signaling map | BCL2, BCL2, BCL2, BCL2, BCL2, BCL2 |
| CCKR signaling map | BCL2L1, BCL2L1, BCL2L1, BCL2L1, BCL2L1, BCL2L1 |
| CCKR signaling map | BAX, Bax, Bax, Bax, BAX, BAX, Bax, Bax, Bax, BAX |
| CCKR signaling map | MCL1, MCL1, MCL1, MCL1, Mcl1 |
| CCKR signaling map | MYC, MYC, MYC, Myc, MYC, Myc, Myc, Myc |
| CCKR signaling map | FOXO1 |
| CCKR signaling map | COX2, COX2, COX2 |
| CCKR signaling map | ITGAV, ITGAV, ITGAV |
| CCKR signaling map | FOS, Fos, FOS, fos, fos, fos, FOS, fos, fos, fos, fos, Fos, fos, FOS, fos, FOS, FOS, FOS, Fos, fos, Fos, Fos |
| CCKR signaling map | MAPK1, MAPK1, MAPK1, MAPK1, MAPK1 |
| CCKR signaling map | AKT1 |
| CCKR signaling map | PAK1, PAK1 |
| CCKR signaling map | TACR1, TACR1 |
| CCKR signaling map | EGR1 |
| Cell adhesion molecules | CLDN4, CLDN3, CLDN7, VCAN, CTLA4, CADM1, NECTIN3, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DRB1, HLA-E, HLA-G, ICAM1, ITGA6, ITGAV, ITGB1, ITGB2, L1CAM, NCAM1, PECAM1, NECTIN1, SDC1, SELE, SELP, CLDN5, VCAM1, CD4, CD40, CD40LG, CDH1, CD34, CD40, HLA-DRA, CD40LG, SDC4 |
| Cell cycle | CDKN1A, CDKN1B, CDKN2A, CHEK2, GSK3B, HDAC1, HDAC2, SMAD3, SMAD4, MYC, ATM, PCNA, PLK1, RB1, CCND1, TGFB1, TGFB2, TP53, YWHAH, CCNB1 |
| Cellular senescence | PIK3CA |
| Central carbon metabolism in cancer | EGFR, ERBB2, AKT1, FGFR1, FGFR2, FLT3, MTOR, HIF1A, KIT, KRAS, MET, MYC, NRAS, PDGFRA, PIK3CA, PIK3R1, MAPK1, PTEN, TP53, PIK3CA |
| cGMP | INS, CREB1, AGTR1, EDNRA, AKT1, PLCB1, ATP1B4, INSR, NOS3, PLCB3, MAPK1, IRS2, CREB3L1, RHOA, ATF2 |
| Chagas disease | ACE, AKT1, PLCB1, FOS, IFNG, FAS, IL1B, IL2, FASLG, IL6, CXCL8, IL10, IL12A, JUN, SMAD3, NFKB1, NOS2, SERPINE1, PIK3CA, PIK3R1, PLCB3, TLR9, MAPK1, RELA, CCL2, CCL3, CCL5, TGFB1, TGFB2, TLR2, TLR4, TNF, TNFRSF1A, C3, MAPK8, PIK3CA |
| Chemical carcinogenesis | NAT2, CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2C19, CYP2E1, AKR1C2, EPHX1, GSTM1, GSTP1, GSTT1, ARNT, PTGS2 |
| Chemokine signaling pathway | CXCL13, CXCR6, CCR9, CCR1, CCR5, CRK, AKT1, PLCB1, CXCR3, CXCL1, CXCL2, GSK3B, CXCL8, CXCR1, CXCR2, CXCL10, KRAS, NFKB1, NRAS, PAK1, PIK3CA, PIK3R1, PLCB3, MAPK1, PTK2, CXCL16, RELA, CCL2, CCL3, CCL5, CCL7, CCL16, CCL17, CCL19, CCL21, CCL22, CCL25, CXCL5, CX3CL1, CXCL12, SHC1, SRC, BRAF, STAT3, CCR2, CXCR4, JAK2, CCL11, PIK3CA, RHOA, CCR8, CCR7, CDC42, CXCL6, RAC1 |
| Choline metabolism in cancer | MAPK8, EGF, EGFR, EIF4EBP1, AKT1, FOS, MTOR, HIF1A, JUN, KRAS, NRAS, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLA2G4A, MAPK1, PIK3CA, RAC1 |
| Cholinergic synapse | JAK2, CREB1, CREB3L1, PIK3CA, AKT1, PLCB1, FOS, FYN, KRAS, NRAS, PIK3CA, PIK3R1, PLCB3, MAPK1, BCL2 |
| Chronic myeloid leukemia | CDKN1A, CDKN1B, CDKN2A, CRK, AKT1, HDAC1, HDAC2, KRAS, SMAD3, SMAD4, MYC, NFKB1, NRAS, PIK3CA, PIK3R1, MAPK1, RB1, CCND1, RELA, BCL2L1, SHC1, BRAF, TGFB1, TGFB2, TP53, STAT5A, PIK3CA |
| Circadian clock system | Clock |
| Circadian entrainment | CREB1, PLCB1, FOS, PLCB3, MAPK1 |
| Circadian rhythm | CREB1, CLOCK |
| Citrate cycle | ACLY |
| Cocaine addiction | CREB1, CREB3L1, ATF2, DRD2, JUN, MAOA, NFKB1, RELA, BDNF |
| Collecting duct acid secretion | CA2 |
| Colorectal cancer | MAPK8, CTNNB1, AKT1, FOS, GSK3B, MSH6, BIRC5, JUN, KRAS, SMAD3, SMAD4, MLH1, MSH2, MYC, PIK3CA, PIK3R1, MAPK1, BAX, CCND1, BCL2, BRAF, TGFB1, TGFB2, TP53, CASP3, PIK3CA, RHOA, RAC1 |
| Complement and coagulation cascades | F2, CPB2, A2M, F2R, F3, FGA, ITGB2, MBL2, SERPINE1, SERPINB2, PLAT, PLAU, PLAUR, C3, C4A, C5, C4BPA, SERPINA1, CPB2, CLU |
| Cortisol synthesis and secretion | CREB1, CREB3L1, ATF2 |
| Cortocotropin releasing factor receptor signaling pathway | CRHR1 |
| Cortocotropin releasing factor receptor signaling pathway | CRHR1 |
| Cushing syndrome | CREB1, CREB3L1, ATF2 |
| Cysteine and methionine metabolism | GCLC, DNMT1, DNMT3A, DNMT3B, MAT2A, ADI1 |
| Cytokine-cytokine receptor interaction | CXCL13, CXCR6, TNFSF13B, CCR9, IL17F, CCR1, CCR5, CNTF, CSF1, CSF1R, CSF2RB, EGF, EGFR, VEGFD, FLT1, FLT3, FLT4, AMH, AMHR2, TNFRSF21, CXCR3, CXCL1, CXCL2, IFNG, FAS, IL1A, IL1B, IL1R1, IL1RAP, IL2, IL2RA, FASLG, IL2RB, IL4, IL5, IL6, IL6R, IL6ST, CXCL8, CXCR1, CXCR2, IL10, IL10RB, IL11, IL11RA, IL12A, IL13, IL15, IL17A, IL18, INHBA, CXCL10, KDR, KIT, LEP, LEPR, LIF, LIFR, LTA, MET, KITLG, TNFRSF11B, IL22, PDGFA, PDGFRA, IL23A, PRL, PRLR, CXCL16, CCL2, CCL3, CCL5, CCL7, CCL16, CCL17, CCL19, CCL21, CCL22, CCL25, CXCL5, CX3CL1, CXCL12, BMPR1B, TGFB1, TGFB2, TNF, TNFRSF1A, TNFRSF1B, CCR2, VEGFA, VEGFC, IL1R2, CXCR4, TSLP, TNFSF10, CXCL14, CD40, CD40LG, CD40, CCL11, CCR8, CCR7, CD40LG, CXCL6, IL20RB, IL20RA, IL24 |
| Cytosolic DNA-sensing pathway | IL1B, IL6, IL18, CXCL10, NFKB1, RELA, CCL5, CASP1, IL33 |
| Dilated cardiomyopathy | IGF1, ITGA6, ITGA2, ITGA3, ITGAV, ITGB1, ITGB3, ITGB5, ITGB6, ACTB, TGFB1, TGFB2, TNF, TPM3 |
| DNA replication | PCNA |
| DNA replication | PCNA |
| Dopaminergic synapse | MAPK8, CREB1, CREB3L1, COMT, DRD2, AKT1, PLCB1, FOS, GSK3B, MAOA, PLCB3, CLOCK, ATF2 |
| Dorso-ventral axis formation | EGFR, KRAS, NOTCH1, NOTCH4, MAPK1, BRAF |
| Drug metabolism - cytochrome P450 | CYP1A2, CYP2A6, CYP2B6, CYP2C19, CYP2E1, GSTM1, GSTP1, GSTT1, MAOA |
| Drug metabolism - other enzymes | NAT2, CYP2A6, TYMP, XDH |
| ECM-receptor interaction | COL4A2, FN1, LAMA1, TNC, ITGA6, ITGA2, ITGA3, ITGAV, ITGB1, ITGB3, ITGB5, ITGB6, LAMA5, LAMC2, SDC1, SPP1, THBS1, CD36, CD44, LAMC1, SDC4, COL4A1 |
| EGF receptor signaling pathway | EGF |
| EGF receptor signaling pathway | EGF |
| EGF receptor signaling pathway | EGF |
| EGF receptor signaling pathway | EGF |
| EGF receptor signaling pathway | EGF |
| EGF receptor signaling pathway | EGF |
| EGF receptor signaling pathway | EGF, EGF |
| EGF receptor signaling pathway | EGF |
| EGF receptor signaling pathway | EGFR, EGFR, EGFR, EGFR |
| EGF receptor signaling pathway | EGF |
| EGFR tyrosine kinase inhibitor resistance | BCL2L11, EGF, EGFR, EIF4EBP1, ERBB2, ERBB3, AKT1, FGF2, FGFR2, MTOR, GAS6, GSK3B, NRG1, IGF1, IGF1R, IL6, IL6R, JAK1, KDR, KRAS, MET, NRAS, PDGFA, PDGFRA, PIK3CA, PIK3R1, AXL, MAPK1, PTEN, BAX, BCL2, BCL2L1, SHC1, SRC, BRAF, STAT3, VEGFA, JAK2, PIK3CA |
| Endocrine and other factor-regulated calcium reabsorption | ESR1, PLCB1, ATP1B4, PLCB3, VDR |
| Endocrine resistance | CDKN1A, CDKN1B, CDKN2A, JAG1, EGFR, ERBB2, AKT1, ESR1, ESR2, FOS, MTOR, GPER1, IGF1, IGF1R, JUN, KRAS, MMP2, MMP9, NOTCH1, NOTCH4, NRAS, PIK3CA, PIK3R1, DLL4, MAPK1, PTK2, BAX, RB1, CCND1, BCL2, SHC1, SRC, BRAF, TP53, MAPK8, PIK3CA |
| Endocytosis | CCR5, CSF1R, EGF, EGFR, ERBB3, F2R, FGFR2, FLT1, FOLR1, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, HSPA6, IGF1R, IGF2R, IL2RA, IL2RB, CXCR1, CXCR2, KDR, KIT, SMAD3, MET, PDGFRA, SRC, TGFB1, TGFB2, CXCR4, RHOA, CDC42 |
| Endometrial cancer | CTNNA1, CTNNB1, EGF, EGFR, ERBB2, AKT1, GSK3B, KRAS, MLH1, MYC, NRAS, PIK3CA, PIK3R1, MAPK1, PTEN, CCND1, BRAF, TP53, CDH1, PIK3CA |
| Epithelial cell signaling in Helicobacter pylori infec | MAPK8, NOD1, EGFR, CXCL1, CXCL8, CXCR1, CXCR2, JUN, MET, NFKB1, PAK1, RELA, CCL5, SRC, ADAM17, CASP3, CDC42, RAC1 |
| Epstein-Barr virus infection | CDKN1A, CDKN1B, AKT1, FCER2, GSK3B, HDAC1, HDAC2, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DRB1, HLA-E, HLA-G, HSPA6, HSPB1, ICAM1, IFNG, IL10, IL10RB, JAK1, JUN, TBPL2, MYC, NFKB1, NFKB2, PIK3CA, PIK3R1, MAP2K7, RB1, BCL2, RELA, STAT3, MAP3K7, TP53, TYK2, VIM, YWHAH, CD40, CD44, MAPK8, CD40, PIK3CA, HLA-DRA, ATF2 |
| ErbB signaling pathway | CDKN1A, CDKN1B, PAK4, CRK, EGF, EGFR, EIF4EBP1, ERBB2, ERBB3, AKT1, MTOR, GSK3B, NRG1, JUN, KRAS, MYC, NRAS, PAK1, PIK3CA, PIK3R1, MAPK1, MAP2K7, PTK2, SHC1, SRC, BRAF, STAT5A, MAPK8, PIK3CA |
| Estrogen signaling pathway | EGFR, AKT1, ESR1, ESR2, FKBP4, FKBP5, PLCB1, FOS, GPER1, HSPA6, HSP90AA1, JUN, KRAS, MMP2, MMP9, NOS3, NRAS, OPRM1, PIK3CA, PIK3R1, PLCB3, MAPK1, SHC1, SRC, CREB1, CREB3L1, PIK3CA, ATF2 |
| Ether lipid metabolism | PLA2G16, PAFAH1B2, PLA2G2A, PLA2G4A |
| Fanconi anemia pathway | MLH1, PMS2, BRCA1, BRCA2 |
| FAS signaling pathway | Fas, Fas, FAS, FAS, FAS, FAS, FAS, FAS, FAS, FAS, Fas, Fas |
| Fat digestion and absorption | APOA1, PLA2G2A, CD36, SCARB1 |
| Fatty acid degradation | ALDH3A2 |
| Fc epsilon RI signaling pathway | MAPK8, AKT1, FCER1G, FYN, IL4, IL5, IL13, KRAS, NRAS, PIK3CA, PIK3R1, PLA2G4A, MAPK1, MAP2K7, TNF, PIK3CA, RAC1 |
| Fc gamma R-mediated phagocytosis | CFL1, CRK, AKT1, LIMK1, PAK1, PIK3CA, PIK3R1, PLA2G4A, MAPK1, PIK3CA, CDC42, RAC1 |
| Ferroptosis | GCLC, CP, ALOX15, HMOX1, TF, TP53 |
| Fluid shear stress and atherosclerosis | CTNNB1, EDN1, AKT1, FOS, GSTM1, GSTP1, GSTT1, HMOX1, HSP90AA1, ICAM1, IFNG, IL1A, IL1B, IL1R1, ITGAV, ITGB3, JUN, KDR, MMP2, MMP9, NFKB1, NOS3, PDGFA, PECAM1, PIK3CA, PIK3R1, PLAT, MAP2K7, PTK2, BCL2, RELA, ACTB, CCL2, SDC1, SELE, BMP4, BMPR1B, SRC, MAP3K7, TNF, TNFRSF1A, TP53, TXN, VCAM1, VEGFA, IL1R2, MAPK8, PIK3CA, RHOA, SDC4, RAC1, NFE2L2 |
| Focal adhesion | PAK4, COL4A2, CRK, CTNNB1, EGF, EGFR, ERBB2, AKT1, VEGFD, FLT1, FLT4, FN1, FYN, LAMA1, GSK3B, TNC, IGF1, IGF1R, ITGA6, ITGA2, ITGA3, ITGAV, ITGB1, ITGB3, ITGB5, ITGB6, JUN, KDR, LAMA5, LAMC2, MET, PAK1, PDGFA, PDGFRA, PIK3CA, PIK3R1, MAPK1, PTEN, PTK2, CCND1, BCL2, ACTB, SHC1, SPP1, SRC, BRAF, THBS1, VEGFA, VEGFC, ACTN4, MAPK8, PIK3CA, LAMC1, RHOA, CDC42, RAC1, COL4A1 |
| FoxO signaling pathway | BCL2L11, CDKN1A, CDKN1B, EGF, EGFR, AKT1, FOXO1, SIRT1, GABARAPL1, IGF1, IGF1R, FASLG, IL6, IL10, INSR, KRAS, SMAD3, SMAD4, ATM, NRAS, PIK3CA, PIK3R1, PLK1, MAPK1, PTEN, CCND1, BCL6, BRAF, STAT3, TGFB1, TGFB2, CAT, IRS2, TNFSF10, CCNB1, MAPK8, INS, PIK3CA, SGK1 |
| Fructose and mannose metabolism | AKR1B1 |
| GABAergic synapse | GABARAPL1, SRC |
| Galactose metabolism | AKR1B1, GALT, PGM1 |
| Gap junction | DRD2, EGF, EGFR, PLCB1, GJA1, KRAS, NRAS, PDGFA, PDGFRA, PLCB3, MAPK1, SRC |
| Gastric acid secretion | CFTR, PLCB1, ATP1B4, PLCB3, ACTB, SST, CA2 |
| Gastric cancer | PIK3CA |
| Glioma | CDKN1A, CDKN2A, EGF, EGFR, AKT1, MTOR, IGF1, IGF1R, KRAS, NRAS, PDGFA, PDGFRA, PIK3CA, PIK3R1, MAPK1, PTEN, RB1, CCND1, SHC1, BRAF, TP53, PIK3CA |
| Glucagon signaling pathway | CREB1, CREB3L1, AKT1, FOXO1, PLCB1, SIRT1, PLCB3, PPARA, ATF2 |
| Glutamatergic synapse | PLCB1, PLA2G4A, PLCB3, MAPK1 |
| Glutathione metabolism | GPX1, GPX3, GSTM1, GSTP1, GSTT1, GCLC |
| Glycerolipid metabolism | ALDH3A2, AKR1B1, LIPC |
| Glycerophospholipid metabolism | PEMT, PLA2G16, PLA2G2A, PLA2G4A |
| Glycine, serine and threonine metabolism | MAOA |
| Glycolysis / Gluconeogenesis | ENO1, ENO2, ALDH3A2, PGM1 |
| Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate | XYLT2 |
| Glycosaminoglycan biosynthesis - heparan sulfate / heparin | XYLT2 |
| Glycosaminoglycan biosynthesis - keratan sulfate | CHST6, CHST2 |
| Glycosaminoglycan degradation | HPSE, NAGLU |
| Glycosphingolipid biosynthesis - globo and isoglobo series | GBGT1 |
| Glyoxylate and dicarboxylate metabolism | CAT |
| GnRH signaling pathway | MAPK8, CGA, EGFR, PLCB1, FSHB, JUN, KRAS, LHB, MMP2, MMP14, NRAS, PLA2G4A, PLCB3, MAPK1, MAP2K7, SRC, CDC42 |
| Graft-versus-host disease | HLA-DRA, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DRB1, HLA-E, HLA-G, IFNG, FAS, IL1A, IL1B, IL2, FASLG, IL6, KIR2DL1, KIR2DL3, KIR3DL1, TNF, KLRD1, KLRC1 |
| Hedgehog signaling pathway | GSK3B, IHH, CCND1, BCL2 |
| Hematopoietic cell lineage | CSF1, CSF1R, FCER2, FLT3, HLA-DPB1, HLA-DQA1, HLA-DRB1, IL1A, IL1B, IL1R1, IL2RA, IL4, IL5, IL6, IL6R, IL11, IL11RA, ITGA6, ITGA2, ITGA3, ITGB3, KIT, KITLG, MME, TNF, IL1R2, CD4, CD36, CD44, CD34, CD1A, HLA-DRA |
| Hepatitis B | CDKN1A, CDKN1B, AKT1, FOS, BIRC5, FAS, FASLG, IL6, CXCL8, JAK1, JUN, KRAS, SMAD3, SMAD4, MMP9, MYC, NFKB1, NRAS, PCNA, PIK3CA, PIK3R1, MAPK1, PTEN, BAX, RB1, CCND1, BCL2, RELA, SRC, STAT3, STAT6, TGFB1, TGFB2, TLR2, TLR3, TLR4, TNF, TP53, CASP3, STAT5A, MAPK8, CREB1, CREB3L1, PIK3CA, STAT4, ATF2 |
| Hepatitis C | CDKN1A, CLDN4, CLDN3, CLDN7, EGF, EGFR, AKT1, GSK3B, CXCL8, JAK1, KRAS, NFKB1, NRAS, PIK3CA, PIK3R1, PPARA, MAPK1, RELA, BRAF, STAT3, TLR3, CLDN5, TNF, TNFRSF1A, TP53, TYK2, SOCS3, SCARB1, MAPK8, PIK3CA, EIF3E |
| Hepatocellular carcinoma | PIK3CA, NFE2L2 |
| Herpes simplex infection | FOS, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DRB1, HLA-E, HLA-G, IFNG, FAS, IL1B, FASLG, IL6, IL12A, IL15, JAK1, JUN, TBPL2, LTA, NFKB1, TLR9, NECTIN1, RELA, CCL2, CCL5, MAP3K7, C1QBP, TLR2, TLR3, TNF, TNFRSF1A, TP53, C3, C5, TYK2, CASP3, SOCS3, CLOCK, CD74, MAPK8, JAK2, HLA-DRA |
| HIF-1 signaling pathway | CDKN1A, CDKN1B, EDN1, EGF, EGFR, EIF4EBP1, ENO1, ENO2, ERBB2, AKT1, FLT1, MTOR, ANGPT1, ANGPT2, HIF1A, HMOX1, IFNG, IGF1, IGF1R, IL6, IL6R, INSR, ARNT, NFKB1, NOS2, NOS3, SERPINE1, PIK3CA, PIK3R1, MAPK1, BCL2, RELA, STAT3, TEK, TF, TIMP1, TLR4, VEGFA, INS, PIK3CA |
| Hippo signaling pathway | YAP1, CTNNA1, CTNNB1, FGF1, AMH, GSK3B, BIRC5, ID1, ITGB2, SMAD3, SMAD4, SMAD7, MYC, SERPINE1, WNT4, CCND1, ACTB, BMP4, BMP6, BMPR1B, SOX2, TGFB1, TGFB2, WNT1, WNT2, WNT5A, WNT7A, YWHAH, LATS1, CDH1, ID2 |
| Hippo signaling pathway -multiple species | YAP1, PAK1, LATS1, RASSF2 |
| Histidine metabolism | ALDH3A2, MAOA |
| Homologous recombination | ATM, BRCA1, BRCA2, XRCC3 |
| HTLV-I infection | CDKN1A, CDKN2A, CHEK2, CTNNB1, EGR1, AKT1, FOS, GSK3B, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DRB1, HLA-E, HLA-G, ICAM1, IL1R1, IL2, IL2RA, IL2RB, IL6, IL15, ITGB2, JAK1, JUN, KRAS, TBPL2, LTA, SMAD3, SMAD4, MYC, ATM, NFKB1, NFKB2, NRAS, PCNA, PDGFA, PDGFRA, PIK3CA, PIK3R1, WNT4, BAX, RB1, CCND1, RELA, BCL2L1, TERT, TGFB1, TGFB2, TNF, TNFRSF1A, TP53, VCAM1, WNT1, WNT2, WNT5A, WNT7A, IL1R2, NRP1, KAT2B, CD40, STAT5A, MAPK8, CREB1, CD40, PIK3CA, HLA-DRA, ATF2 |
| Human cytomegalovirus infection | CREB1 |
| Human immunodeficiency virus 1 infection | MAPK8 |
| Human papillomavirus infection | CREB1, CREB3L1, PIK3CA, LAMC1, CDC42, COL4A1 |
| Huntington disease | BDNF, BDNF, BDNF, BDNF, BDNF, BDNF, BDNF, BDNF, BDNF |
| Huntington's disease | PLCB1, GPX1, HDAC1, HDAC2, TBPL2, COX2, NDUFS1, ATP5A1, PLCB3, PPARG, BAX, BDNF, SOD1, TP53, CASP3, CREB1, CREB3L1, ATP5F1B |
| Hypertrophic cardiomyopathy | ACE, IGF1, IL6, ITGA6, ITGA2, ITGA3, ITGAV, ITGB1, ITGB3, ITGB5, ITGB6, ACTB, TGFB1, TGFB2, TNF, TPM3 |
| IL-17 signaling pathway | IL17F, DEFB4A, ELAVL1, FOS, CXCL1, CXCL2, GSK3B, HSP90AA1, IFNG, IL1B, IL4, IL5, IL6, CXCL8, IL13, IL17A, CXCL10, JUN, MMP1, MMP3, MMP9, MMP13, NFKB1, MAPK1, PTGS2, RELA, CCL2, CCL7, CCL17, CXCL5, MAP3K7, TNF, CASP3, MAPK8, CCL11, CXCL6 |
| Inflammation mediated by chemokine and cytokine signaling pathway | IL2 |
| Inflammatory bowel disease | IL17F, GATA3, TBX21, HLA-DPB1, HLA-DQA1, HLA-DRB1, IFNG, IL1A, IL1B, IL2, IL4, IL5, IL6, IL10, IL12A, IL13, IL17A, IL18, JUN, SMAD3, NFKB1, IL22, FOXP3, IL23A, RELA, NOD2, STAT3, STAT6, TGFB1, TGFB2, TLR2, TLR4, TNF, STAT4 |
| Inflammatory mediator regulation of TRP channels | MAPK8, PIK3CA, F2RL1, PLCB1, IGF1, IL1B, IL1R1, IL1RAP, NGF, PIK3CA, PIK3R1, PLA2G4A, PLCB3, PTGER2, PTGER4, SRC, TRPV1 |
| Influenza A | AKT1, GSK3B, HLA-DPB1, HLA-DQA1, HLA-DRB1, HSPA6, ICAM1, IFNG, FAS, IL1A, IL1B, FASLG, IL6, CXCL8, IL12A, IL18, CXCL10, JAK1, JUN, NFKB1, PIK3CA, PIK3R1, MAPK1, MAP2K7, RELA, ACTB, CCL2, CCL5, TLR3, TLR4, TNF, TNFRSF1A, TYK2, CASP1, TNFSF10, SOCS3, IL33, MAPK8, JAK2, PIK3CA, HLA-DRA, ATF2 |
| Inositol phosphate metabolism | PIK3CA, PLCB1, PIK3CA, PLCB3, PLCD1, PTEN |
| Insulin resistance | AKT1, FOXO1, MTOR, GSK3B, IL6, INSR, NFKB1, NOS3, PIK3CA, PIK3R1, PPARA, PTEN, RELA, STAT3, TNF, TNFRSF1A, IRS2, SOCS3, CD36, MAPK8, INS, CREB1, CREB3L1, PIK3CA |
| Insulin secretion | INS, CREB1, CREB3L1, ATF2, PLCB1, ATP1B4, PLCB3 |
| Insulin signaling pathway | CRK, EIF4EBP1, AKT1, FOXO1, MTOR, GSK3B, INSR, KRAS, NRAS, PIK3CA, PIK3R1, MAPK1, SHC1, BRAF, IRS2, SOCS3, MAPK8, INS, PIK3CA |
| Insulin/IGF pathway-protein kinase B signaling cascade | PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN |
| Integrin signalling pathway | Fyn, Fyn, Fyn, Fyn, Fyn, Fyn, Fyn, Fyn, Fyn, Fyn, Fyn, Fyn |
| Integrin signalling pathway | Src, Src, SRC, SRC, Src, Src, Src, Src |
| Interleukin signaling pathway | mTOR, mTOR |
| Intestinal immune network for IgA production | TNFSF13B, CCR9, HLA-DPB1, HLA-DQA1, HLA-DRB1, IL2, IL4, IL5, IL6, IL10, IL15, CCL25, CXCL12, TGFB1, CXCR4, CD40, CD40LG, CD40, HLA-DRA, CD40LG |
| Jak-STAT signaling pathway | CDKN1A, CNTF, CSF2RB, AKT1, MTOR, IFNG, IL2, IL2RA, IL2RB, IL4, IL5, IL6, IL6R, IL6ST, IL10, IL10RB, IL11, IL11RA, IL12A, IL13, IL15, JAK1, LEP, LEPR, LIF, LIFR, MCL1, MYC, IL22, IL23A, PIK3CA, PIK3R1, PRL, PRLR, CCND1, BCL2, BCL2L1, STAT3, STAT6, TYK2, TSLP, SOCS3, STAT5A, JAK2, PIK3CA, PIAS3, STAT4, IL20RB, IL20RA, IL24 |
| Kaposi's sarcoma-associated herpesvirus infection | MICA, CDKN1A, CCR1, CCR5, CTNNB1, AKT1, FGF2, FOS, GABARAPL1, MTOR, ANGPT2, CXCL1, CXCL2, GSK3B, HIF1A, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, ICAM1, FAS, IL6, IL6ST, CXCL8, JAK1, JUN, KRAS, MICB, MYC, NFKB1, NRAS, PIK3CA, PIK3R1, MAPK1, PTGS2, BAX, RB1, CCND1, RELA, SRC, STAT3, TLR3, TNFRSF1A, TP53, C3, TYK2, VEGFA, CASP3, MAPK8, JAK2, CREB1, PIK3CA, CCR8, RAC1 |
| Legionellosis | CXCL1, CXCL2, HSF1, HSPA6, HSPD1, IL1B, IL6, CXCL8, IL12A, IL18, ITGB2, NFKB1, NFKB2, RELA, TLR2, TLR4, TNF, C3, CASP1, CASP3 |
| Leishmaniasis | FOS, HLA-DPB1, HLA-DQA1, HLA-DRB1, IFNG, IL1A, IL1B, IL4, IL10, IL12A, ITGB1, ITGB2, JAK1, JUN, NFKB1, NOS2, MAPK1, PTGS2, RELA, MAP3K7, TGFB1, TGFB2, TLR2, TLR4, TNF, C3, JAK2, HLA-DRA |
| Leukocyte transendothelial migration | CLDN4, CLDN3, CLDN7, CTNNA1, CTNNB1, ICAM1, ITGB1, ITGB2, MMP2, MMP9, PECAM1, PIK3CA, PIK3R1, PTK2, ACTB, CXCL12, CLDN5, VCAM1, CXCR4, ACTN4, PIK3CA, RHOA, CDC42, RAC1 |
| Linoleic acid metabolism | PLA2G16, CYP1A2, CYP2C19, CYP2E1, ALOX15, PLA2G2A, PLA2G4A |
| Long-term depression | CRH, CRHR1, PLCB1, IGF1, IGF1R, KRAS, NRAS, PLA2G4A, PLCB3, MAPK1, BRAF |
| Long-term potentiation | PLCB1, KRAS, NRAS, PLCB3, MAPK1, BRAF |
| Longevity regulating pathway | EHMT2, EIF4EBP1, AKT1, FOXO1, SIRT1, MTOR, IGF1, IGF1R, INSR, KRAS, NFKB1, NRAS, PIK3CA, PIK3R1, PPARG, BAX, RELA, TP53, CAT, IRS2, ADIPOQ, INS, CREB1, CREB3L1, ADIPOR2, PIK3CA, ADIPOR1, ATF2 |
| Longevity regulating pathway | INS, CRYAB, AKT1, FOXO1, SIRT1, MTOR, HDAC1, HDAC2, HSPA6, IGF1, IGF1R, INSR, KRAS, NRAS, PIK3CA, PIK3R1, SOD1, CAT, IRS2, PIK3CA |
| Lysine degradation | EHMT2, EZH2, ALDH3A2, SUV39H1, SUV39H2 |
| Lysosome | CTSB, CTSD, CTSG, IGF2R, NAGLU, PSAP |
| Malaria | ICAM1, IFNG, IL1B, IL6, CXCL8, IL10, IL12A, IL18, ITGB2, MET, PECAM1, TLR9, CCL2, SDC1, SELE, SELP, TGFB1, TGFB2, THBS1, TLR2, TLR4, TNF, VCAM1, CD36, CD40, CD40LG, CD40, KLRK1, CD40LG |
| MAPK signaling pathway | CRK, DUSP2, EGF, EGFR, AKT1, FGF1, FGF2, FGFR1, FGFR2, FOS, HSPA6, HSPB1, FAS, IL1A, IL1B, IL1R1, FASLG, JUN, KRAS, STMN1, MYC, NFKB1, NFKB2, NGF, NRAS, NTF4, NTRK2, PAK1, PDGFA, PDGFRA, PLA2G4A, MAPK1, MAP2K7, PTPRR, RELA, BDNF, BRAF, MAP3K7, TGFB1, TGFB2, TNF, TNFRSF1A, TP53, IL1R2, CASP3, MAPK8, INS, CDC42, RAC1, ATF2 |
| Maturity onset diabetes of the young | INS, HNF1B, NR5A2 |
| Measles | CDKN1B, AKT1, FYN, GSK3B, HSPA6, IFNG, FAS, IL1A, IL1B, IL2, IL2RA, FASLG, IL2RB, IL4, IL6, IL12A, IL13, JAK1, NFKB1, PIK3CA, PIK3R1, TLR9, CCND1, RELA, STAT3, TACR1, MAP3K7, TLR2, TLR4, TP53, TYK2, TNFSF10, STAT5A, JAK2, PIK3CA |
| Melanogenesis | CREB1, CTNNB1, EDN1, PLCB1, GSK3B, KIT, KRAS, KITLG, NRAS, PLCB3, WNT4, MAPK1, WNT1, WNT2, WNT5A, WNT7A, CREB3L1 |
| Melanoma | CDKN1A, CDKN2A, EGF, EGFR, AKT1, FGF1, FGF2, FGFR1, IGF1, IGF1R, KRAS, MET, NRAS, PDGFA, PDGFRA, PIK3CA, PIK3R1, MAPK1, PTEN, RB1, CCND1, BRAF, TP53, CDH1, PIK3CA |
| Metabolic pathways | NAT2, HPSE, PLA2G16, COMT, CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP2C19, CYP2E1, CYP11A1, CYP17A1, CYP19A1, CYP26A1, DAD1, DNMT1, DNMT3A, DNMT3B, TYMP, ENO1, ENO2, ALDH3A2, AKR1B1, PLCB1, FOLH1, ALOX15, GALT, GBGT1, AMY2A, GSTZ1, HMOX1, HMOX2, HSD3B2, HSD17B1, HSD17B3, HSD17B2, IDO1, ARG2, LAMA5, LIPC, MAOA, MAT2A, COX2, MTHFR, NAGLU, ACLY, NDUFS1, NME1, NOS2, NOS3, ATP5A1, PAFAH1B2, HSD17B7, ACP1, PGM1, PLA2G2A, PLA2G4A, PLCB3, PLCD1, PON1, ADI1, PTGDS, PTGS1, PTGS2, XYLT2, AKR1D1, XDH, PTGES2, AKR1C3, PTGES, PRDX6, SMPD3, CYP24A1, PEMT, ATP5F1B, PNP, GCLC |
| Metabolism of xenobiotics by cytochrome P450 | CYP1A1, CYP1A2, CYP1B1, CYP2A6, CYP2B6, CYP2E1, AKR1C1, EPHX1, GSTM1, GSTP1, GSTT1 |
| MicroRNAs in cancer | BCL2L11, CDKN1A, CDKN1B, CDKN2A, PAK4, CRK, CYP1B1, DNMT1, DNMT3A, DNMT3B, EGFR, ERBB2, ERBB3, EZH2, DICER1, SIRT1, MTOR, FOXP1, HDAC1, HMOX1, TNC, ITGB3, KRAS, STMN1, MIRLET7A1, MIRLET7B, MIRLET7D, MIR100, MIR122, MIR125A, MIR125B2, MIR126, MIR135A1, MIR141, MIR143, MIR145, MIR150, MIR183, MIR194-1, MIR199A1, MIR20A, MIR200A, MIR200B, MIR21, MIR210, MIR222, MIR223, MIR29C, MIR34A, MIR34C, MIR9-1, MIR99A, MCL1, MET, MMP9, MIR135B, MYC, ATM, NFKB1, NOTCH1, NOTCH4, NRAS, PDGFA, PDGFRA, ABCB1, PIK3CA, PLAU, MAPK1, PTEN, PTGS2, CCND1, BCL2, MIR483, SHC1, BRCA1, STAT3, TGFB2, THBS1, TIMP3, TP53, VEGFA, VIM, HMGA2, CASP3, TP63, IRS2, CD44, PIK3CA, MIR23B, MIR23A, RHOA, CYP24A1, MIR451A, MIR125B1 |
| Mineral absorption | ATP1B4, HMOX1, HMOX2, ATP7A, TF, VDR |
| Mismatch repair | MSH6, MLH1, MSH2, PCNA, PMS2 |
| Mitophagy | MAPK8, GABARAPL1, HIF1A, JUN, KRAS, NRAS, RELA, BCL2L1, SRC, TP53 |
| Morphine addiction | OPRM1 |
| mRNA surveillance pathway | MSI1 |
| mTOR signaling pathway | EIF4EBP1, AKT1, MTOR, GSK3B, IGF1, IGF1R, INSR, KRAS, NRAS, PIK3CA, PIK3R1, WNT4, MAPK1, PTEN, BRAF, TNF, TNFRSF1A, WNT1, WNT2, WNT5A, WNT7A, CAB39L, INS, PIK3CA, RHOA, SGK1 |
| N-Glycan biosynthesis | DAD1 |
| Natural killer cell mediated cytotoxicity | MICA, FCER1G, FYN, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, ICAM1, IFNG, FAS, FASLG, ITGB2, KIR2DL1, KIR2DL3, KIR2DS4, KIR3DL1, KRAS, MICB, NRAS, PAK1, PIK3CA, PIK3R1, MAPK1, SHC1, BRAF, TNF, ULBP2, CASP3, TNFSF10, NCR1, PIK3CA, KLRK1, RAC1, KLRD1, KLRC1, KIR2DS5 |
| Necroptosis | ALOX15, H2AFX, HMGB1, HSP90AA1, IFNG, FAS, IL1A, IL1B, FASLG, JAK1, PLA2G4A, BAX, BCL2, STAT3, STAT6, TLR3, TLR4, TNF, TNFRSF1A, TYK2, CASP1, TNFSF10, IL33, STAT5A, MAPK8, JAK2, STAT4 |
| Neuroactive ligand-receptor interaction | CGA, CRHR1, CRHR2, CTSG, DRD2, AGTR1, AGTR2, EDNRA, F2R, F2RL1, LPAR3, FPR1, FSHB, FSHR, NR3C1, LEP, LEPR, LHB, LHCGR, OPRM1, OXTR, PRL, PRLR, PTGER2, PTGER3, PTGER4, PTGFR, HRH4, SSTR1, SSTR5, TACR2, TACR1, TRPV1, KISS1R, F2, RXFP1, P2RX3 |
| Neurotrophin signaling pathway | CRK, AKT1, GSK3B, FASLG, JUN, KRAS, NFKB1, NGF, NRAS, NTF4, NTRK2, PIK3CA, PIK3R1, MAPK1, MAP2K7, BAX, BCL2, RELA, BDNF, SHC1, BRAF, TP53, MAPK8, PIK3CA, RHOA, CDC42, RAC1 |
| NF-kappa B signaling pathway | TNFSF13B, CXCL2, ICAM1, IL1B, IL1R1, CXCL8, LTA, ATM, NFKB1, NFKB2, PLAU, PTGS2, BCL2, RELA, BCL2L1, CCL19, CCL21, CXCL12, MAP3K7, TLR4, TNF, TNFRSF1A, VCAM1, CD40, CD40LG, CD40, CD40LG |
| Nicotinate and nicotinamide metabolism | PNP |
| Nicotine degradation | CYP2A6 |
| Nicotine degradation | CYP2A6, CYP2A6 |
| Nicotinic acetylcholine receptor signaling pathway | CAT, CAT, CAT |
| Nitrogen metabolism | CA2 |
| NOD-like receptor signaling pathway | NOD1, CTSB, PLCB1, GABARAPL1, CXCL1, CXCL2, HSP90AA1, IL1B, IL6, CXCL8, IL18, JAK1, JUN, NFKB1, PLCB3, MAPK1, BCL2, RELA, BCL2L1, CCL2, CCL5, NOD2, MAP3K7, TLR4, TNF, TXN, TYK2, CASP1, MAPK8, RHOA |
| Non | STAT5A, CDKN2A, PIK3CA, EGF, EGFR, ERBB2, AKT1, FHIT, KRAS, NRAS, PIK3CA, PIK3R1, MAPK1, RB1, CCND1, BRAF, STAT3, TP53 |
| Non-alcoholic fatty liver disease | BCL2L11, CYP2E1, AKT1, GSK3B, FAS, IL1A, IL1B, FASLG, IL6, IL6R, CXCL8, INSR, JUN, LEP, LEPR, COX2, NDUFS1, NFKB1, PIK3CA, PIK3R1, PPARA, BAX, RELA, TGFB1, TNF, TNFRSF1A, CASP3, IRS2, SOCS3, ADIPOQ, MAPK8, INS, CDC42, RAC1 |
| Non-homologous end-joining | XRCC4 |
| Notch signaling pathway | JAG1, HDAC1, HDAC2, HES5, NOTCH1, NOTCH4, DLL4, ADAM17, KAT2B |
| Nucleotide excision repair | PCNA |
| One carbon pool by folate | MTHFR |
| Oocyte meiosis | INS, IGF1, IGF1R, AR, PGR, PLK1, MAPK1, AURKA, YWHAH, CCNB1 |
| Osteoclast differentiation | CSF1, CSF1R, AKT1, FOS, FYN, IFNG, IL1A, IL1B, IL1R1, ITGB3, JAK1, JUN, NFKB1, NFKB2, TNFRSF11B, PIK3CA, PIK3R1, PPARG, MAPK1, MAP2K7, RELA, MAP3K7, TGFB1, TGFB2, TNF, TNFRSF1A, TYK2, SOCS3, MAPK8, CREB1, PIK3CA, LILRB1, LILRB2, RAC1 |
| Ovarian steroidogenesis | INS, CGA, CYP1A1, CYP1B1, CYP11A1, CYP17A1, CYP19A1, FSHB, FSHR, GDF9, HSD3B2, HSD17B1, HSD17B2, IGF1, IGF1R, INSR, LHB, LHCGR, HSD17B7, PLA2G4A, PTGS2, BMP6, STAR, AKR1C3, SCARB1 |
| Oxidative phosphorylation | COX2, NDUFS1, ATP5A1, ATP5F1B |
| Oxytocin signaling pathway | CDKN1A, EGFR, PLCB1, FOS, JUN, KRAS, NOS3, NRAS, OXTR, PLA2G4A, PLCB3, MAPK1, PTGS2, CCND1, ACTB, SRC, RHOA |
| p53 pathway | HDAC1, HDAC1 |
| p53 pathway feedback loops 2 | ATM |
| p53 pathway feedback loops 2 | ATM |
| p53 pathway feedback loops 2 | PTEN, PTEN, PTEN, PTEN, PTEN, PTEN, PTEN |
| p53 signaling pathway | CDKN1A, CDKN2A, CHEK2, IGF1, IGFBP3, FAS, CD82, ATM, SERPINE1, RPRM, PTEN, BAX, CCND1, THBS1, TP53, CASP3, CCNB1 |
| Pancreatic cancer | CDKN2A, EGF, EGFR, ERBB2, AKT1, JAK1, KRAS, SMAD3, SMAD4, NFKB1, PIK3CA, PIK3R1, MAPK1, RB1, CCND1, RELA, BCL2L1, BRAF, BRCA2, STAT3, TGFB1, TGFB2, TP53, VEGFA, MAPK8, PIK3CA, CDC42, RAC1 |
| Pancreatic secretion | RHOA, CFTR, CPB2, PLCB1, ATP1B4, AMY2A, PLA2G2A, PLCB3, CA2, RAC1, CPB2 |
| Parathyroid hormone synthesis, secretion and action | CREB1, CREB3L1, RHOA, CYP24A1, ATF2 |
| Parkinson's disease | PARK7, DRD2, COX2, NDUFS1, ATP5A1, UCHL1, CASP3, ATP5F1B |
| Pathogenic Escherichia coli infection | RHOA, CTNNB1, FYN, ITGB1, ACTB, TLR4, CDH1, CDC42 |
| Pathways in cancer | CDKN1A, CDKN1B, CDKN2A, COL4A2, CRK, CSF1R, CTNNA1, CTNNB1, AGTR1, EDNRA, EGF, EGFR, ERBB2, AKT1, F2R, FGF1, FGF2, FGFR1, FGFR2, VEGFD, FOXO1, FLT3, PLCB1, FN1, FOS, LPAR3, MTOR, LAMA1, GSK3B, GSTP1, MSH6, HDAC1, HDAC2, HIF1A, BIRC5, HSP90AA1, IGF1, IGF1R, KLK3, FAS, FASLG, IL6, CXCL8, ITGA6, AR, ITGA2, ITGA3, ITGAV, ITGB1, JAK1, JUN, KIT, KRAS, LAMA5, LAMC2, ARNT, SMAD3, SMAD4, MET, KITLG, MLH1, MMP1, MMP2, MMP9, MSH2, MYC, NFKB1, NFKB2, NOS2, NRAS, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB3, WNT4, PPARG, MAPK1, PTEN, PTGER2, PTGER3, PTGER4, PTGS2, PTK2, BAX, RB1, CCND1, BCL2, RELA, BCL2L1, CXCL12, BMP4, BRAF, BRCA2, STAT3, TGFB1, TGFB2, TP53, TPM3, VEGFA, VEGFC, WNT1, WNT2, WNT5A, WNT7A, CXCR4, CASP3, CDH1, STAT5A, MAPK8, JAK2, PIK3CA, LAMC1, RHOA, CDC42, STAT4, RAC1, NFE2L2, DAPK1, COL4A1 |
| pathway_name | gene_symbol |
| Pentose and glucuronate interconversions | AKR1B1 |
| Pentose phosphate pathway | PGM1 |
| Peroxisome | NOS2, SOD1, XDH, CAT |
| Pertussis | NOD1, CFL1, FOS, IL1A, IL1B, IL6, CXCL8, IL10, IL12A, ITGB1, ITGB2, JUN, NFKB1, NOS2, IL23A, MAPK1, RELA, CXCL5, SFTPA1, TLR4, TNF, C3, C4A, C5, CASP1, CASP3, MAPK8, RHOA, C4BPA, CXCL6 |
| Phagosome | HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DRB1, HLA-E, HLA-G, ITGA2, ITGAV, ITGB1, ITGB2, ITGB3, ITGB5, MBL2, MPO, ACTB, SFTPA1, THBS1, TLR2, TLR4, C3, CD36, SCARB1, HLA-DRA, RAC1, MRC1 |
| Phenylalanine metabolism | MAOA, MIF |
| Phosphatidylinositol signaling system | PIK3CA, PLCB1, PIK3CA, PIK3R1, PLCB3, PLCD1, PTEN |
| Phospholipase D signaling pathway | AGTR1, EGF, EGFR, AKT1, F2R, FCER1G, PLCB1, LPAR3, MTOR, FYN, CXCL8, CXCR1, CXCR2, INSR, KIT, KRAS, KITLG, NRAS, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLA2G4A, PLCB3, MAPK1, PTGFR, SHC1, INS, PIK3CA, RHOA |
| PI3 kinase pathway | IGFBP1 |
| PI3K-Akt signaling pathway | BCL2L11, CDKN1A, CDKN1B, COL4A2, CSF1, CSF1R, EFNA1, EGF, EGFR, EIF4EBP1, AKT1, F2R, FGF1, FGF2, FGFR1, FGFR2, VEGFD, FLT1, FLT4, FN1, LPAR3, MTOR, ANGPT1, LAMA1, ANGPT2, GSK3B, HSP90AA1, TNC, IGF1, IGF1R, IL2, IL2RA, FASLG, IL2RB, IL4, IL6, IL6R, INSR, ITGA6, ITGA2, ITGA3, ITGAV, ITGB1, ITGB3, ITGB5, ITGB6, JAK1, KDR, KIT, KRAS, LAMA5, LAMC2, MCL1, MET, KITLG, MYC, NFKB1, NGF, NOS3, NRAS, PDGFA, PDGFRA, PIK3CA, PIK3R1, MAPK1, PRL, PRLR, PTEN, PTK2, CCND1, BCL2, RELA, BCL2L1, SPP1, BRCA1, TEK, THBS1, TLR2, TLR4, TP53, VEGFA, VEGFC, YWHAH, JAK2, INS, CREB1, CREB3L1, PIK3CA, LAMC1, SGK1, RAC1, ATF2, COL4A1 |
| Platelet activation | AKT1, F2R, FCER1G, FGA, PLCB1, FYN, ITGA2, ITGB1, ITGB3, NOS3, PIK3CA, PIK3R1, PLA2G4A, PLCB3, MAPK1, PTGS1, ACTB, SRC, PIK3CA, RHOA |
| Platinum drug resistance | CDKN1A, CDKN2A, ERBB2, AKT1, GSTM1, GSTP1, GSTT1, MSH6, BIRC5, FAS, FASLG, MLH1, MSH2, ATM, PIK3CA, PIK3R1, ATP7A, MAPK1, BAX, BCL2, BCL2L1, BRCA1, TP53, CASP3, PIK3CA |
| Porphyrin and chlorophyll metabolism | CP, HMOX1, HMOX2 |
| PPAR signaling pathway | APOA1, APOA2, MMP1, PPARA, PPARG, ADIPOQ, CD36 |
| Primary bile acid biosynthesis | AKR1D1 |
| Primary immunodeficiency | CD40, CD40LG, CD4, CD40, CD40LG, CD79A |
| Prion diseases | LAMC1, EGR1, FYN, IL1A, IL1B, IL6, NCAM1, NOTCH1, MAPK1, BAX, CCL5, SOD1, C5, STIP1 |
| Progesterone | MAPK8, INS, AKT1, HSP90AA1, IGF1, IGF1R, KRAS, PGR, PIK3CA, PIK3R1, PLK1, MAPK1, BRAF, CCNB1, PIK3CA |
| Prolactin signaling pathway | CGA, CYP17A1, AKT1, ESR1, ESR2, FOS, GALT, GSK3B, KRAS, LHB, LHCGR, NFKB1, NRAS, PIK3CA, PIK3R1, MAPK1, PRL, PRLR, CCND1, RELA, SHC1, SRC, STAT3, SOCS3, STAT5A, MAPK8, JAK2, PIK3CA, INS |
| Prostate cancer | CDKN1A, CDKN1B, CTNNB1, EGF, EGFR, ERBB2, AKT1, FGFR1, FGFR2, FOXO1, MTOR, GSK3B, GSTP1, HSP90AA1, IGF1, IGF1R, KLK3, AR, KRAS, NFKB1, NRAS, PDGFA, PDGFRA, PIK3CA, PIK3R1, MAPK1, PTEN, RB1, CCND1, BCL2, RELA, SRD5A2, BRAF, TP53, INS, CREB1, CREB3L1, PIK3CA |
| Proteasome | IFNG |
| Protein digestion and absorption | COL4A2, COL5A2, CPB2, ATP1B4, MME, COL18A1, CPB2, COL4A1 |
| Protein processing in endoplasmic reticulum | MAPK8, CRYAB, DAD1, HSPA6, HSP90AA1, MAP2K7, BAX, BCL2, NFE2L2 |
| Proteoglycans in cancer | CDKN1A, HPSE, CTNNB1, EGFR, ERBB2, ERBB3, AKT1, ESR1, FGF2, FGFR1, FN1, MTOR, HIF1A, IGF1, IGF1R, IGF2, IHH, FAS, FASLG, ITGA2, ITGAV, ITGB1, ITGB3, ITGB5, KDR, KRAS, MIR21, MET, MMP2, MMP9, MYC, NRAS, PAK1, PIK3CA, PIK3R1, PLAU, PLAUR, WNT4, MAPK1, PTK2, CCND1, ACTB, SDC1, SRC, BRAF, STAT3, TGFB1, TGFB2, THBS1, TIMP3, TLR2, TLR4, TNF, TP53, VEGFA, WNT1, WNT2, WNT5A, WNT7A, NANOG, CASP3, CD44, PIK3CA, RHOA, DCN, CDC42, SDC4, RAC1 |
| Proximal tubule bicarbonate reclamation | ATP1B4, CA2 |
| Purine metabolism | FHIT, NME1, PGM1, XDH, PNP |
| Pyrimidine metabolism | PNP, TYMP, NME1 |
| Pyruvate metabolism | ALDH3A2 |
| Rap1 signaling pathway | CRK, CSF1, CSF1R, CTNNB1, DRD2, EFNA1, EGF, EGFR, AKT1, F2R, FGF1, FGF2, FGFR1, FGFR2, VEGFD, FLT1, PLCB1, FLT4, LPAR3, FPR1, ANGPT1, ANGPT2, ID1, IGF1, IGF1R, INSR, ITGB1, ITGB2, ITGB3, KDR, KIT, KRAS, MET, KITLG, NGF, NRAS, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLCB3, MAPK1, ACTB, SRC, BRAF, TEK, THBS1, VEGFA, VEGFC, CDH1, INS, PIK3CA, RHOA, CDC42, RAC1 |
| Ras signaling pathway | PAK4, PLA2G16, CSF1, CSF1R, EFNA1, EGF, EGFR, AKT1, FGF1, FGF2, FGFR1, FGFR2, VEGFD, FLT1, FLT4, ANGPT1, ANGPT2, IGF1, IGF1R, FASLG, INSR, KDR, KIT, KRAS, MET, KITLG, NFKB1, NGF, NRAS, PAK1, PDGFA, PDGFRA, PIK3CA, PIK3R1, PLA2G2A, PLA2G4A, MAPK1, RELA, BCL2L1, SHC1, TEK, VEGFA, VEGFC, KSR1, MAPK8, INS, PIK3CA, RHOA, CDC42, RAC1 |
| Regulation of actin cytoskeleton | PAK4, CFL1, CRK, EGF, EGFR, F2R, FGF1, FGF2, FGFR1, FGFR2, FN1, ITGA6, ITGA2, ITGA3, ITGAV, ITGB1, ITGB2, ITGB3, ITGB5, ITGB6, KRAS, LIMK1, NRAS, PAK1, PDGFA, PDGFRA, PIK3CA, PIK3R1, MAPK1, PTK2, ACTB, SRC, BRAF, ACTN4, INS, F2, PIK3CA, RHOA, CDC42, RAC1 |
| Regulation of lipolysis in adipocytes | INS, CGA, PLA2G16, AKT1, INSR, PIK3CA, PIK3R1, PTGER3, PTGS1, PTGS2, IRS2, PIK3CA, NPY |
| Relaxin signaling pathway | MAPK8, CREB1, CREB3L1, RXFP1, PIK3CA, ATF2, COL4A1 |
| Renal cell carcinoma | PAK4, CRK, AKT1, HIF1A, JUN, KRAS, ARNT, MET, NRAS, PAK1, PIK3CA, PIK3R1, MAPK1, BRAF, TGFB1, TGFB2, VEGFA, PIK3CA, CDC42, RAC1 |
| Renin secretion | CREB1, CTSB, ACE, AGTR1, EDNRA, PLCB1, PLCB3, PTGER2, PTGER4 |
| Renin-angiotensin system | CMA1, CTSG, ACE, AGTR1, AGTR2, MME |
| Retinol metabolism | CYP1A1, CYP1A2, CYP2A6, CYP2B6, CYP26A1 |
| Retrograde endocannabinoid signaling | MAPK8, PLCB1, NDUFS1, PLCB3, MAPK1, PTGS2 |
| Rheumatoid arthritis | TNFSF13B, CSF1, CTLA4, FLT1, FOS, ANGPT1, CXCL1, HLA-DPB1, HLA-DQA1, HLA-DRB1, ICAM1, IFNG, IL1A, IL1B, IL6, CXCL8, IL11, IL15, IL17A, IL18, ITGB2, JUN, MMP1, MMP3, IL23A, CCL2, CCL3, CCL5, CXCL5, CXCL12, TEK, TGFB1, TGFB2, TLR2, TLR4, TNF, VEGFA, HLA-DRA, CXCL6 |
| Riboflavin metabolism | ACP1 |
| Ribosome | RPL41 |
| RIG-I-like receptor signaling pathway | MAPK8, CXCL8, IL12A, CXCL10, NFKB1, RELA, MAP3K7, TNF |
| RNA degradation | TOB1, ENO1, ENO2, HSPD1 |
| RNA transport | EIF4EBP1, EIF3E |
| Salivary secretion | PLCB1, ATP1B4, AQP5, LPO, PLCB3 |
| Salmonella infection | MAPK8, FOS, CXCL1, CXCL2, IFNG, IL1A, IL1B, IL6, CXCL8, IL18, JUN, NFKB1, NOS2, MAPK1, RELA, ACTB, CCL3, TLR4, CASP1, CDC42, RAC1 |
| Serotonergic synapse | CYP2C19, PLCB1, ALOX15, KRAS, MAOA, NRAS, PLA2G4A, PLCB3, MAPK1, PTGS1, PTGS2, SLC6A4, BRAF, CASP3 |
| Shigellosis | MAPK8, NOD1, CRK, CXCL8, ITGB1, NFKB1, MAPK1, RELA, ACTB, NOD2, SRC, CD44, CDC42, RAC1 |
| Signaling pathways regulating pluripotency of stem cells | CTNNB1, DLX5, AKT1, FGF2, FGFR1, FGFR2, GSK3B, ID1, IGF1, IGF1R, IL6ST, INHBA, JAK1, KRAS, LIF, LIFR, SMAD3, SMAD4, MEIS1, MYC, NODAL, NRAS, PIK3CA, PIK3R1, WNT4, POU5F1, MAPK1, BMP4, BMPR1B, SOX2, STAT3, WNT1, WNT2, WNT5A, WNT7A, NANOG, JAK2, PIK3CA, ID2 |
| Small cell lung cancer | CDKN1B, COL4A2, AKT1, FN1, LAMA1, ITGA6, ITGA2, ITGA3, ITGAV, ITGB1, LAMA5, LAMC2, MYC, NFKB1, NOS2, PIK3CA, PIK3R1, PTEN, PTGS2, PTK2, RB1, CCND1, BCL2, RELA, BCL2L1, TP53, PIK3CA, LAMC1, FHIT, COL4A1 |
| SNARE interactions in vesicular transport | STX5 |
| Sphingolipid metabolism | SMPD3, SGPP2 |
| Sphingolipid signaling pathway | MAPK8, CTSD, AKT1, FCER1G, PLCB1, FYN, KRAS, NFKB1, NOS3, NRAS, PIK3CA, PIK3R1, PLCB3, MAPK1, PTEN, BAX, BCL2, RELA, TNF, TNFRSF1A, TP53, PIK3CA, RHOA, SGPP2, RAC1 |
| Spliceosome | HSPA6 |
| Staphylococcus aureus infection | HLA-DRA, FPR1, HLA-DPB1, HLA-DQA1, HLA-DRB1, ICAM1, IL10, ITGB2, MBL2, SELP, C3, C4A, C5 |
| Starch and sucrose metabolism | AMY2A, PGM1 |
| Steroid biosynthesis | CYP24A1, HSD17B7 |
| Steroid hormone biosynthesis | COMT, CYP1A1, CYP1A2, CYP1B1, CYP2E1, CYP11A1, CYP17A1, CYP19A1, AKR1C1, AKR1C2, HSD3B2, HSD11B2, HSD17B1, HSD17B3, HSD17B2, STS, HSD17B7, SRD5A2, AKR1D1, AKR1C3, SULT1E1, SRD5A1, STS |
| Systemic lupus erythematosus | CD40, HLA-DRA, HIST2H3C, CTSG, H2AFX, HLA-DPB1, HLA-DQA1, HLA-DRB1, IFNG, IL10, TNF, C3, C4A, C5, ACTN4, HIST3H3, CD40, CD40LG, CD40LG |
| T cell activation | jun, jun, JUN, jun, jun, JUN, JUN, jun, jun, JUN, JUN, jun, jun, jun, JUN, jun, jun, jun |
| T cell receptor signaling pathway | PAK4, CTLA4, AKT1, FOS, FYN, GSK3B, IFNG, IL2, IL4, IL5, IL10, JUN, KRAS, NFKB1, NRAS, PAK1, PIK3CA, PIK3R1, MAPK1, MAP2K7, RELA, MAP3K7, TNF, CD4, CD40LG, PIK3CA, RHOA, CDC42, CD40LG |
| Taste transduction | P2RX3 |
| TGF-beta signaling pathway | FST, AMH, AMHR2, ID1, IFNG, INHBA, SMAD3, SMAD4, SMAD7, MYC, NODAL, MAPK1, BMP4, BMP6, BMPR1B, TGFB1, TGFB2, THBS1, TNF, RHOA, DCN, ID2 |
| Th1 and Th2 cell differentiation | JAG1, FOS, GATA3, TBX21, HLA-DPB1, HLA-DQA1, HLA-DRB1, IFNG, IL2, IL2RA, IL2RB, IL4, IL5, IL12A, IL13, JAK1, JUN, NFKB1, NOTCH1, DLL4, MAPK1, RELA, STAT6, TYK2, RUNX3, CD4, STAT5A, MAPK8, JAK2, MAF, HLA-DRA, STAT4 |
| Th17 cell differentiation | IL17F, AHR, FOS, MTOR, GATA3, TBX21, HIF1A, HLA-DPB1, HLA-DQA1, HLA-DRB1, HSP90AA1, IFNG, IL1B, IL1R1, IL1RAP, IL2, IL2RA, IL2RB, IL4, IL6, IL6R, IL6ST, IL17A, JAK1, JUN, SMAD3, SMAD4, NFKB1, IL22, FOXP3, IL23A, MAPK1, RELA, STAT3, STAT6, TGFB1, TYK2, CD4, STAT5A, MAPK8, JAK2, HLA-DRA |
| Thermogenesis | CREB1, CREB3L1, ATP5F1B, ATF2 |
| Thiamine metabolism | ACP1 |
| Thyroid cancer | CTNNB1, KRAS, MYC, NRAS, PPARG, MAPK1, CCND1, BRAF, TP53, TPM3, CDH1 |
| Thyroid hormone signaling pathway | CTNNB1, AKT1, ESR1, FOXO1, PLCB1, ATP1B4, MTOR, GSK3B, HDAC1, HDAC2, HIF1A, ITGAV, ITGB3, KRAS, MYC, NOTCH1, NOTCH4, NRAS, PIK3CA, PIK3R1, PLCB3, PLCD1, WNT4, MAPK1, CCND1, ACTB, BMP4, SRC, TP53, KAT2B, PIK3CA |
| Thyroid hormone synthesis | CREB1, CREB3L1, CGA, PLCB1, ATP1B4, GPX1, GPX3, PLCB3, ATF2 |
| Tight junction | MAPK8, CFTR, CLDN4, CLDN3, CLDN7, ERBB2, HSPA4, ITGB1, JUN, PCNA, MAP2K7, CCND1, ACTB, SRC, CLDN5, ACTN4, CD1A, RHOA, CDC42, RAC1 |
| TNF signaling pathway | CSF1, JAG1, EDN1, AKT1, FOS, CXCL1, CXCL2, ICAM1, FAS, IL1B, IL6, IL15, CXCL10, JUN, LIF, LTA, MMP3, MMP9, MMP14, NFKB1, PIK3CA, PIK3R1, MAPK1, MAP2K7, PTGS2, RELA, CCL2, CCL5, CXCL5, CX3CL1, SELE, NOD2, MAP3K7, TNF, TNFRSF1A, TNFRSF1B, VCAM1, VEGFC, CASP3, SOCS3, MAPK8, CREB1, CREB3L1, PIK3CA, ATF2 |
| Toll receptor signaling pathway | TLR4 |
| Toll receptor signaling pathway | TLR3 |
| Toll-like receptor signaling pathway | AKT1, FOS, IL1B, IL6, CXCL8, IL12A, CXCL10, JUN, NFKB1, PIK3CA, PIK3R1, TLR9, MAPK1, MAP2K7, RELA, CCL3, CCL5, SPP1, MAP3K7, TLR2, TLR3, TLR4, TNF, CD40, MAPK8, CD40, PIK3CA, RAC1 |
| Toxoplasmosis | CCR5, AKT1, LAMA1, HLA-DPB1, HLA-DQA1, HLA-DRB1, HSPA6, IFNG, IL10, IL10RB, IL12A, ITGA6, ITGB1, JAK1, LAMA5, LAMC2, NFKB1, NOS2, MAPK1, BCL2, RELA, BCL2L1, STAT3, MAP3K7, TGFB1, TGFB2, TLR2, TLR4, TNF, TNFRSF1A, TYK2, CASP3, CD40, CD40LG, MAPK8, JAK2, CD40, LAMC1, HLA-DRA, CD40LG |
| Transcriptional misregulation in cancer | CDKN1A, CDKN1B, HIST2H3C, CSF1R, FOXO1, FLT1, FLT3, HDAC1, HDAC2, HOXA10, HOXA11, HPGD, IGF1, IGF1R, IGFBP3, IL2RB, IL6, CXCL8, MEIS1, MET, MMP3, MMP9, MPO, MYC, ATM, NFKB1, PDGFA, PLAT, PLAU, PPARG, PTK2, RELA, BCL2L1, BCL6, TP53, WT1, IL1R2, HMGA2, HIST3H3, PROM1, CD40, CD40, MAF, ID2 |
| Tryptophan metabolism | CYP1A1, CYP1A2, CYP1B1, ALDH3A2, IDO1, MAOA, CAT |
| Tuberculosis | CTSD, AKT1, FCER1G, HLA-DPB1, HLA-DQA1, HLA-DRB1, HSPD1, IFNG, IL1A, IL1B, IL6, IL10, IL10RB, IL12A, IL18, ITGB2, JAK1, NFKB1, NOS2, IL23A, TLR9, MAPK1, BAX, BCL2, RELA, NOD2, SRC, TGFB1, TGFB2, TLR2, TLR4, TNF, TNFRSF1A, C3, VDR, CASP3, KSR1, CD74, MAPK8, JAK2, CREB1, RHOA, HLA-DRA, MRC1 |
| Type I diabetes mellitus | INS, HLA-DRA, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DRB1, HLA-E, HLA-G, HSPD1, IFNG, FAS, IL1A, IL1B, IL2, FASLG, IL12A, LTA, TNF |
| Type II diabetes mellitus | MAPK8, INS, PIK3CA, MTOR, INSR, PIK3CA, PIK3R1, MAPK1, TNF, IRS2, SOCS3, ADIPOQ |
| Tyrosine metabolism | COMT, GSTZ1, MAOA, MIF |
| Ubiquitin mediated proteolysis | PIAS3, BRCA1, SOCS3 |
| Valine, leucine and isoleucine degradation | ALDH3A2 |
| Vascular smooth muscle contraction | CALD1, RHOA, AGTR1, EDNRA, PLCB1, PLA2G2A, PLA2G4A, PLCB3, MAPK1, BRAF |
| Vasopressin | CREB1, CREB3L1, AQP2 |
| VEGF signaling pathway | AKT1, HSPB1, KDR, KRAS, NOS3, NRAS, PIK3CA, PIK3R1, PLA2G4A, MAPK1, PTGS2, PTK2, SRC, VEGFA, PIK3CA, CDC42, RAC1 |
| Vibrio cholerae infection | CFTR, MUC2, ACTB |
| Viral carcinogenesis | CDKN1A, CDKN1B, CDKN2A, CCR5, HDAC1, HDAC2, HLA-A, HLA-B, HLA-C, HLA-E, HLA-G, IL6ST, JAK1, JUN, KRAS, TBPL2, NFKB1, NFKB2, NRAS, PIK3CA, PIK3R1, MAPK1, BAX, RB1, CCND1, RELA, SRC, STAT3, TP53, C3, YWHAH, ACTN4, CASP3, KAT2B, STAT5A, CREB1, CREB3L1, PIK3CA, RHOA, CCR8, CDC42, RAC1, ATF2 |
| Viral myocarditis | CD40, HLA-DRA, FYN, HLA-A, HLA-B, HLA-C, HLA-DPB1, HLA-DQA1, HLA-DRB1, HLA-E, HLA-G, ICAM1, ITGB2, CCND1, ACTB, CASP3, CD40, CD40LG, CD40LG, RAC1 |
| Vitamin D metabolism and pathway | VDR |
| Vitamin digestion and absorption | FOLH1, APOA1, SCARB1 |
| Wnt signaling pathway | MAPK8, CTNNB1, DKK1, PLCB1, GSK3B, JUN, SMAD3, SMAD4, MMP7, MYC, SERPINF1, PLCB3, WNT4, CCND1, SFRP4, MAP3K7, TP53, WNT1, WNT2, WNT5A, WNT7A, RHOA, RAC1 |
| Wnt signaling pathway | Smad4, Smad4 |
| Wnt signaling pathway | Smad4, Smad4 |
| Wnt signaling pathway | Smad4, Smad4 |