Results
| PMID | 24999736 |
| Gene Name | TP53 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | p53 codon 72 polymorphism |
| Population size | 3,809 |
| Population details | 3809 (1,803 patients, 2,006 controls) |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
|
Immunol Invest. 2014;43(6):595-605. doi: 10.3109/08820139.2013.833623. Song, Gwan Gyu| Lee, Young Ho Division of Rheumatology, Department of Internal Medicine, Korea University College of Medicine , Seoul , Korea. OBJECTIVE: The aim of this study was to determine whether the p53 codon 72 polymorphism is associated with susceptibility to endometriosis. METHODS: A meta-analysis was conducted on the associations between the p53 codon 72 polymorphism and endometriosis using 1) allele contrast, 2) a recessive model, 3) a dominant model, and 4) homozygote contrast. RESULTS: Nine studies involving 1,803 patients and 2,006 controls were considered in the meta-analysis. Meta-analysis of the p53 polymorphism showed no association between endometriosis and the p53 C allele (odds ratio (OR) = 1.087, 95% confidence interval (CI) = 0.921-1.282, p = 0.323). Stratification by ethnicity indicated no association between the p53 C allele and endometriosis in Europeans and Latin Americans. However, a significant association was found between the p53 C allele and endometriosis in East Asians (OR = 1.405, 95% CI = 1.065-1.854, p = 0.016). Furthermore, association was found between the p53 polymorphism and endometriosis in East Asians using the dominant model (OR = 2.046, 95% CI = 1.123-3.730, p = 0.019). CONCLUSIONS: This meta-analysis demonstrates that the p53 codon 72 polymorphism may be associated with susceptibility to endometriosis in East Asians, but not in Europeans and Latin Americans. Mesh Terms: Alleles| Codon/genetics| Endometriosis/*genetics| *Ethnic Groups| Female| Genetic Association Studies| Genetic Predisposition to Disease| Humans| Polymorphism, Genetic| Tumor Suppressor Protein p53/*genetics|DA 2015/04/17 06:00 |
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