Results
| PMID | 20045518 |
| Gene Name | PTP4A3 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 155 |
| Population details | 155 (105 women with histopathologically confirmed endometriosis, 50 women with histopathologically assessed normal endometria) |
| Sex | Female |
| Associated genes | PRL-3 |
| Other associated phenotypes |
Endometriosis |
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Fertil Steril. 2010 Nov;94(6):1980-4. doi: 10.1016/j.fertnstert.2009.10.065. Epub Ruan, Fei| Lin, Jun| Wu, Rui-Jin| Xu, Kai-Hong| Zhang, Xin-Mei| Zhou, Cai-Yun| Huang, Xiu-Feng Department of Obstetrics and Gynecology, Women's Hospital, School of Medicine, Zhejiang University, Hangzhou, People's Republic of China. OBJECTIVE: To investigate the expression of phosphatase of regenerating liver-3 (PRL-3) in ectopic, eutopic, and normal endometria and explore its relationship with endometriosis. DESIGN: A clinical retrospective and molecular study. SETTING: Department of obstetrics, gynecology, and reproductive medicine. PATIENT(S): One hundred and five women with histopathologically confirmed endometriosis, and 50 women with histopathologically assessed normal endometria. INTERVENTION(S): Immunohistochemical staining and Western blot analysis. MAIN OUTCOME MEASURE(S): Expression of PRL-3 protein. RESULT(S): As shown by the immunohistochemical analysis, PRL-3 was mainly located in the cytoplasm and membrane. The cells that tested positive for PRL-3 were detected in endometriotic tissues that did not occur in eutopic and normal endometria. Statistical analysis indicated that the expression of PRL-3 was closely associated with the clinical stages and recurrence of endometriosis. CONCLUSION(S): Expression of PRL-3 is related to the clinical stages and recurrence of endometriosis, which provides use with a novel marker and promising target in the treatment of human endometriosis. Mesh Terms: Adult| Biomarkers/analysis/metabolism| Blotting, Western| Endometriosis/diagnosis/*metabolism/pathology| Female| Humans| Immunohistochemistry| Middle Aged| Neoplasm Proteins/metabolism/*physiology| Protein Tyrosine Phosphatases/metabolism/*physio |
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