Results
| PMID | 17997748 |
| Gene Name | TNF |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 70 |
| Population details | 70 (46 had histology-proven endometriosis, 24 patients without endometriosis participated as controls) |
| Age | 19–48 years |
| Sex | Female |
| Other associated phenotypes |
Endometriosis |
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Am J Reprod Immunol. 2007 Dec;58(6):497-504. Cho, Si Hyun| Oh, Yoon Jin| Nam, Anna| Kim, Hye Yeon| Park, Joo Hyun| Kim, Jae Hoon| Park, Ki Hyun| Cho, Dong Je| Lee, Byung Seok Department of Obstetrics and Gynecology, Yongdong Severance Hospital, Yonsei University, College of Medicine, Dogok-dong, KangNam-gu, Seoul, Korea. PROBLEM: The aim of this study was to evaluate serum and urinary levels of vascular endothelial growth factors, tumor necrosis factor-alpha (TNF-alpha), and soluble fms-like tyrosine kinase (sFlt-1) in patients with endometriosis. METHOD OF STUDY: During surgery for pelvic pain, pelvic mass or infertility, serum and urine were collected. Of 70 patients, 46 had histology-proven endometriosis and 24 patients without endometriosis participated as controls. RESULTS: Serum TNF-alpha levels and urinary sFlt-1 levels corrected for creatinine excretion were significantly increased in the endometriosis group (P=0.001 and P=0.011 respectively). Serum sFlt-1 levels and urinary sFlt-1 levels corrected for creatinine were significantly higher in patients with minimal-to-mild disease (P=0.014 and P=0.015 respectively), where serum TNF-alpha levels were increased in moderate-to-severe endometriosis (P<0.001). CONCLUSION: The pathogenesis of minimal-to-mild endometriosis and moderate-to-severe endometriosis seems to be different. Increased sFlt-1 levels in serum and urine of minimal-to-mild disease indicate that sFlt-1 may have an important role in inhibiting angiogenic process of the disease. Mesh Terms: Adult| Angiogenesis Inducing Agents/*blood/*urine| Endometriosis/*blood/*urine| Female| Humans| Middle Aged| Tumor Necrosis Factor-alpha/biosynthesis/blood/urine| Vascular Endothelial Growth Factor A/biosynthesis/blood/urine| Vascular Endothelial |
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