Results
| PMID | 16310857 |
| Gene Name | LIF |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 15 |
| Population details | 15 (8 controls, 7 patients with endometriosis ) |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | IL-11, IL-11Ralpha and LIF |
| Other associated phenotypes |
Endometriosis associated infertility |
|
J Reprod Immunol. 2006 Feb;69(1):53-64. Epub 2005 Nov 28. Dimitriadis, Evdokia| Stoikos, Chelsea| Stafford-Bell, Martyn| Clark, Ian| Paiva, Premila| Kovacs, Gabor| Salamonsen, Lois A Prince Henry's Institute of Medical Research, P.O. Box 5152, Clayton, Vic. 3168, Australia. evdokia.dimitriadis@phimr.monash.edu.au Interleukin (IL)-11 is essential for embryo implantation in the mouse and evidence suggests it has a role in implantation in humans. This study has evaluated immunoreactive IL-11, IL-11 receptor (R) alpha and leukemia inhibitory factor (LIF) in endometrium of infertile women with endometriosis (I/E) and normal fertile women (controls) during the implantation window. Endometrial biopsies from I/E (N = 7) were timed from the LH surge and were post-ovulatory days (POD) 5-10. Control biopsies (N = 8) from women were between days 19 and 24 of the menstrual cycle. Staining intensity of IL-11, IL-11Ralpha and LIF evaluated using semi-quantitative immunohistochemistry scores. Immunoreactive IL-11, IL-11Ralpha and LIF were present predominantly in glandular epithelium, while luminal epithelium showed patchy staining. All controls stained positively for IL-11, IL-11Ralpha and LIF in glandular epithelium. IL-11 and IL-11Ralpha staining was absent from glandular epithelium in cohorts of I/E. LIF staining intensity in glandular epithelium was significantly lower in I/E compared to controls. The results suggest that reduced endometrial IL-11 and/or LIF may contribute to infertility in some endometriotic women. Mesh Terms: Adult| Embryo Implantation/immunology| Endometriosis/*immunology| Endometrium/chemistry/*immunology| Female| Humans| Immunohistochemistry| Infertility, Female/*immunology| Interleukin-11/*metabolism| Interleukin-11 Receptor alpha Subunit| Interl |
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