Results
| PMID | 16045019 |
| Gene Name | TNF |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 150 |
| Population details | 150 (82 patients with EMS, 68 controls) |
| Sex | Female |
| Associated genes | TNF-alpha,TNF-beta |
| Other associated phenotypes |
Endometriosis |
|
Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2005 Jun;30(3):304-6. Luo, Min| He, Yuan-Li| Peng, Dong-Xian| Liu, Mu-Biao| Chen, Yan-Ying Department of Obstetrics and Gynecology, Zhujiang Hospital, First Military Medical University, Guangzhou 510282, China. OBJECTIVE: To evaluate the levels of tumor necrosis factor-alpha (TNF-alpha) and tumor necrosis factor-beta (TNF-beta) before and after conservative laparoscopic surgery in patients with endometriosis. METHODS: The levels of TNF-alpha and TNF-beta in the serum of both 82 patients with EMS and 68 controls were determined by ELISA. RESULTS: The levels of TNF-alpha and TNF-beta in the serum of patients with EMS were significantly higher than those of the controls (P < 0.01), and they increased with the clinical terms ( P < 0.05). After clearance of endometrosis foci with laparoscopic conservative surgery, the TNF-alpha levels decreased significantly in EMS III - IV, and TNF-beta levels decreased significantly in EMS I - IV. CONCLUSION: Measuring TNF-alpha and TNF-beta levels in the serum of patients with EMS may have important value in postoperative follow-up, surveillance and evaluation of the effectiveness of the surgery. Mesh Terms: Adolescent| Adult| Endometriosis/*blood/surgery| Female| Follow-Up Studies| Humans| Laparoscopy| Lymphotoxin-alpha/*blood| Tumor Necrosis Factor-alpha/*metabolism|DA 2006/09/02 09:00 |
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