Results
| PMID | 15036718 |
| Gene Name | TP53 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 47 |
| Population details | 47 (17 cases of endometriosis/cancer, 6 atypical endometriosis, 17 cases with endometriosis, 7 endometrium) |
| Sex | Female |
| Associated genes | p53, c-erb-B-2, MIB1 and Bcl-2 |
| Other associated phenotypes |
Endometriosis, ovarian cancer |
|
Eur J Obstet Gynecol Reprod Biol. 2004 Mar 15;113(1):87-93. Sainz de la Cuesta, Ricardo| Izquierdo, Manuel| Canamero, Marta| Granizo, Juan Jose| Manzarbeitia, Felix Departments de Obstetricia y Ginecologia, Anatomia Patologica y Epidemiologia, Fundacion Jimenez Diaz, Universidad Autonoma de Madrid, Avenida de los Reyes Catolicos, 2, 28040 Madrid, Spain. OBJECTIVE: To evaluate the expression of p53, c-erb-B-2, MIB1 and Bcl-2 in normal endometrium, endometriosis, atypical endometriosis and ovarian cancer associated with endometriosis, looking for immunohistochemical markers that may help determine endometriosis with premalignant potential. STUDY DESIGN: Between 1948 and 1999, 410 epithelial ovarian cancers and 521 cases of endometriosis were surgically treated at Fundacion Jimenez Diaz. Pathology reports and slides were reviewed. Four groups were defined: (1) endometriosis/cancer (n=17); (2) atypical endometriosis (n=6); (3) endometriosis (n=17); (4) endometrium (n=7). Tumors and controls were immunostained and evaluated for expression of p53, c-erb-B-2, MIB1 and Bcl-2. Statistical analysis was performed using Chi-square for linear trends, Fisher exact and Kruskal-Wallis tests. RESULTS: Of the 410 cancers, 17 (4.1%) had associated endometriosis and of the 521 endometriosis, 6 (1.2 %) had atypical changes. Fourteen of 17 (82.4%) cancers associated with endometriosis and all atypical endometriosis had p53 overexpression. Only 2 of 17 (11.8%) endometriosis and none of the endometriums had mutant p53 (P<0.01). We found a trend towards increased expression of MIB1 (0.073) in the cancer and atypical endometriosis groups, and no differences in expression of Bcl-2 or c-erb-B-2. The sensitivity and specificity of p53 as a marker for the diagnosis of atypical endometriosis and cancer associated with endometriosis were 87%; CI 95% (73.2-100%) and 92% (80.6-100%), respectively. When comparing all groups, the mean positive p53 and MIB1 cell count was statistically significant (P=0.01). CONCLUSIONS: Overexpression of p53 in atypical endometriosis and cancer associated with endometriosis is a common finding and may be used to identify endometriosis with premalignant potential. Mesh Terms: Adult| Aged| Biomarkers, Tumor/*genetics| Endometriosis/epidemiology/*genetics| Female| Gene Expression Regulation, Neoplastic| Genes, erbB-2/genetics| Genes, p53/*genetics| Humans| Ki-67 Antigen/genetics| Middle Aged| Ovarian Neoplasms/epidemi |
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