Results
| PMID | 11779589 |
| Gene Name | TP53 |
| Condition | Endometriosis |
| Association |
Associated |
| Mutation | p53 codon 72 polymorphisms |
| Population size | 258 |
| Population details | 258 (118 having moderate or severe endometriosis, 140 with no endometriosis) |
| Sex | Female |
| Associated genes | p53 |
| Other associated phenotypes |
Endometriosis |
|
Fertil Steril. 2002 Jan;77(1):43-5. Chang, Chi Chen| Hsieh, Yao Yuan| Tsai, Fuu Jen| Tsai, Chang Hai| Tsai, Horng Der| Lin, Cheng Chieh Department of Obstetrics and Gynecology, China Medical College Hospital, Taichung, Taiwan. OBJECTIVE: To evaluate the association between endometriosis and the p53 polymorphism. DESIGN: Prospective study. SETTING: Department of gynecology and genetics in a medical center. PATIENT(S): Women with and without endometriosis. INTERVENTION(S): Women were categorized as having moderate or severe endometriosis (n = 118) or no endometriosis (n = 140). MAIN OUTCOME MEASURE(S): Polymerase chain reaction was used to detect p53 codon 72 polymorphisms (arginine homozygosity, heterozygosity, and proline homozygosity). Associations between endometriosis and p53 polymorphisms were evaluated. RESULT(S): The distributions of different p53 polymorphisms differed significantly between groups. The respective proportions of arginine homozygotes, heterozygotes, and proline homozygotes were 10.2%, 66.9%, and 22.9% in the group with endometriosis and 30.7%, 50%, and 19.3% in the group without endometriosis. CONCLUSION(S): Endometriosis is associated with p53 polymorphism. p53 arginine homozygotes have lower risk for endometriosis. Heterozygotes and proline homozygotes have higher risk for endometriosis. Mesh Terms: Amino Acid Substitution| Asian Continental Ancestry Group| Codon/*genetics| Endometriosis/*genetics/surgery| Female| *Genes, p53| Genotype| Humans| Polymerase Chain Reaction| *Polymorphism, Genetic| *Proline| Reference Values| Taiwan| Tumor S |
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