Gene id
969
Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references
Gene Summary
Gene Symbol
CD69 Gene UCSC Ensembl
Aliases
AIM, BL-AC/P26, CLEC2C, EA1, GP32/28, MLR-3
Gene name
CD69 molecule
Alternate names
early activation antigen CD69, C-type lectin domain family 2, member C, CD69 antigen (p60, early T-cell activation antigen), activation inducer molecule (AIM/CD69), early T-cell activation antigen p60, early lymphocyte activation antigen, leukocyte surface anti,
Gene location
12p13.31 (9760900: 9752485) Exons: 5 NC_000012.12
Gene summary(Entrez)
This gene encodes a member of the calcium dependent lectin superfamily of type II transmembrane receptors. Expression of the encoded protein is induced upon activation of T lymphocytes, and may play a role in proliferation. Furthermore, the protein may act to transmit signals in natural killer cells and platelets. [provided by RefSeq, Aug 2011]
OMIM
107273
Protein Summary
Protein general information
Q07108 Name: Early activation antigen CD69 (Activation inducer molecule) (AIM) (BL AC/P26) (C type lectin domain family 2 member C) (EA1) (Early T cell activation antigen p60) (GP32/28) (Leukocyte surface antigen Leu 23) (MLR 3) (CD antigen CD69)Length: 199 Mass: 22,559 Tissue specificity: Expressed on the surface of activated T-cells, B-cells, natural killer cells, neutrophils, eosinophils, epidermal Langerhans cells and platelets.Sequence
MSSENCFVAENSSLHPESGQENDATSPHFSTRHEGSFQVPVLCAVMNVVFITILIIALIALSVGQYNCPGQYTFS MPSDSHVSSCSEDWVGYQRKCYFISTVKRSWTSAQNACSEHGATLAVIDSEKDMNFLKRYAGREEHWVGLKKEPG HPWKWSNGKEFNNWFNVTGSDKCVFLKNTEVSSMECEKNLYWICNKPYK Structural information
Other Databases
GeneCards: CD69; Malacards: CD69
Gene ontology
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GO accession Term name Evidence code Go category
GO:0004888
transmembrane signaling r eceptor activity
TAS
molecular_function
GO:0005509
calcium ion binding
IEA
molecular_function
GO:0005515
protein binding
IPI
molecular_function
GO:0005887
integral component of pla sma membrane
TAS
cellular_component
GO:0007165
signal transduction
IEA
biological_process
GO:0009897
external side of plasma m embrane
IEA
cellular_component
GO:0030246
carbohydrate binding
IEA
molecular_function
GO:0035690
cellular response to drug
IEA
biological_process
GO:0004888
transmembrane signaling r eceptor activity
TAS
molecular_function
GO:0005509
calcium ion binding
IEA
molecular_function
GO:0005515
protein binding
IPI
molecular_function
GO:0005887
integral component of pla sma membrane
TAS
cellular_component
GO:0007165
signal transduction
IEA
biological_process
GO:0009897
external side of plasma m embrane
IEA
cellular_component
GO:0016020
membrane
IEA
cellular_component
GO:0016020
membrane
IEA
cellular_component
GO:0016021
integral component of mem brane
IEA
cellular_component
GO:0030246
carbohydrate binding
IEA
molecular_function
GO:0035690
cellular response to drug
IEA
biological_process
GO:0004888
transmembrane signaling r eceptor activity
TAS
molecular_function
GO:0005515
protein binding
IPI
molecular_function
GO:0005887
integral component of pla sma membrane
TAS
cellular_component
Diseases
Associated diseases
References
Addison's disease PMID: 18593762
Diabetes PMID: 19430480
Endometriosis PMID: 16533339
Recurrent pregnancy loss (RPL)/ Abortion/ Miscarriage/ Recurrent pregnancy failure/Pregnancy loss/ Recurrent miscarriage/ Spontaneous abortion PMID: 11331628
Rheumatoid arthritis PMID: 18627570
Endometriosis INFBASE15259373
Unexplained infertility PMID: 24597237
PubMed references
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PMID
Condition
Mutation
Ethnicity
Population details
Infertility_type
Associated_genes
Abstract
16533339
Endometrio sis
CD56 CD95 CD69
Show abstract
15259373
Endometrio sis
48 (30 patients with laparosco pically diagnos ed early endome triosis, 18 hea lthy controls)
CD69
Show abstract