Endometriosis Knowledgebase

Search Result

Gene id

6366

Gene Summary SNPs Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

CCL21 Gene UCSC Ensembl

Aliases

6Ckine, CKb9, ECL, SCYA21, SLC, TCA4

Gene name

C-C motif chemokine ligand 21

Alternate names

C-C motif chemokine 21, Efficient Chemoattractant for Lymphocytes, beta chemokine exodus-2, chemokine (C-C motif) ligand 21, secondary lymphoid tissue chemokine, small inducible cytokine subfamily A (Cys-Cys), member 21,

Gene location

9p13.3 (34710166: 34709004) Exons: 4 NC_000009.12

Gene summary(Entrez)

This antimicrobial gene is one of several CC cytokine genes clustered on the p-arm of chromosome 9. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. Similar to other chemokines the protein encoded by this gene inhibits hemopoiesis and stimulates chemotaxis. This protein is chemotactic in vitro for thymocytes and activated T cells, but not for B cells, macrophages, or neutrophils. The cytokine encoded by this gene may also play a role in mediating homing of lymphocytes to secondary lymphoid organs. It is a high affinity functional ligand for chemokine receptor 7 that is expressed on T and B lymphocytes and a known receptor for another member of the cytokine family (small inducible cytokine A19). [provided by RefSeq, Sep 2014]

OMIM

602737

SNPs

rs2812378

Strand:    Allele origin:   Allele change: C/G/T   Mutation type: snp

CM000671.2   g.34710263G>A
CM000671.2   g.34710263G>C
NC_000009.11   g.34710260G>A
NC_000009.12   g.34710263G>A
NC_000009.12   g.34710263G>C
NM_002989.3   c.-197C>G
NM_002989.3   c.-197C>T
XR_242544.1   n.124+7225G>A

Protein Summary

Protein general information

O00585

Name: C C motif chemokine 21 (6Ckine) (Beta chemokine exodus 2) (Secondary lymphoid tissue chemokine) (SLC) (Small inducible cytokine A21)

Length: 134 Mass: 14,646

Tissue specificity: Highly expressed in high endothelial venules of lymph nodes, spleen and appendix. Intermediate levels found in small intestine, thyroid gland and trachea. Low level expression in thymus, bone marrow, liver, and pancreas. Also found in

Sequence

MAQSLALSLLILVLAFGIPRTQGSDGGAQDCCLKYSQRKIPAKVVRSYRKQEPSLGCSIPAILFLPRKRSQAELC
ADPKELWVQQLMQHLDKTPSPQKPAQGCRKDRGASKTGKKGKGSKGCKRTERSQTPKGP

Structural information

Interpro:	IPR030593 IPR034133 IPR001811
Pfam:	PF00048
CDD:	cd01119
PDB:	2L4N 5EKI
PDBsum:	2L4N 5EKI
DIP:	5854
MINT:	123964
STRING:	ENSP00000259607;

Other Databases

GeneCards: CCL21; Malacards: CCL21

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0001768	establishment of T cell p olarity	IDA	biological_process
GO:0001771	immunological synapse for mation	ISS	biological_process
GO:0001954	positive regulation of ce ll-matrix adhesion	IDA	biological_process
GO:0001954	positive regulation of ce ll-matrix adhesion	IDA	biological_process
GO:0002407	dendritic cell chemotaxis	IDA	biological_process
GO:0002548	monocyte chemotaxis	IBA	biological_process
GO:0002606	positive regulation of de ndritic cell antigen proc essing and presentation	ISS	biological_process
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IBA	cellular_component
GO:0005622	intracellular	IEA	cellular_component
GO:0006954	inflammatory response	NAS	biological_process
GO:0006955	immune response	TAS	biological_process
GO:0007186	G-protein coupled recepto r signaling pathway	IDA	biological_process
GO:0007267	cell-cell signaling	TAS	biological_process
GO:0008009	chemokine activity	IDA	molecular_function
GO:0008009	chemokine activity	IDA	molecular_function
GO:0010560	positive regulation of gl ycoprotein biosynthetic p rocess	ISS	biological_process
GO:0030838	positive regulation of ac tin filament polymerizati on	IDA	biological_process
GO:0031274	positive regulation of ps eudopodium assembly	IDA	biological_process
GO:0031295	T cell costimulation	ISS	biological_process
GO:0031529	ruffle organization	IDA	biological_process
GO:0031732	CCR7 chemokine receptor b inding	ISS	molecular_function
GO:0033630	positive regulation of ce ll adhesion mediated by i ntegrin	IDA	biological_process
GO:0034695	response to prostaglandin E	IDA	biological_process
GO:0035759	mesangial cell-matrix adh esion	IDA	biological_process
GO:0042379	chemokine receptor bindin g	IDA	molecular_function
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological_process
GO:0043552	positive regulation of ph osphatidylinositol 3-kina se activity	IDA	biological_process
GO:0043552	positive regulation of ph osphatidylinositol 3-kina se activity	IDA	biological_process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological_process
GO:0046330	positive regulation of JN K cascade	IDA	biological_process
GO:0048020	CCR chemokine receptor bi nding	IBA	molecular_function
GO:0048247	lymphocyte chemotaxis	IBA	biological_process
GO:0048260	positive regulation of re ceptor-mediated endocytos is	ISS	biological_process
GO:0048469	cell maturation	ISS	biological_process
GO:0050921	positive regulation of ch emotaxis	ISS	biological_process
GO:0051209	release of sequestered ca lcium ion into cytosol	IDA	biological_process
GO:0051491	positive regulation of fi lopodium assembly	IDA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0060326	cell chemotaxis	IDA	biological_process
GO:0070098	chemokine-mediated signal ing pathway	IBA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0071346	cellular response to inte rferon-gamma	IBA	biological_process
GO:0071347	cellular response to inte rleukin-1	IBA	biological_process
GO:0071356	cellular response to tumo r necrosis factor	IBA	biological_process
GO:0090023	positive regulation of ne utrophil chemotaxis	IDA	biological_process
GO:0090630	activation of GTPase acti vity	IDA	biological_process
GO:0097026	dendritic cell dendrite a ssembly	ISS	biological_process
GO:1903237	negative regulation of le ukocyte tethering or roll ing	IDA	biological_process
GO:2000107	negative regulation of le ukocyte apoptotic process	IDA	biological_process
GO:2000147	positive regulation of ce ll motility	IDA	biological_process
GO:2000406	positive regulation of T cell migration	IDA	biological_process
GO:2000529	positive regulation of my eloid dendritic cell chem otaxis	IDA	biological_process
GO:2000548	negative regulation of de ndritic cell dendrite ass embly	ISS	biological_process
GO:0001768	establishment of T cell p olarity	IDA	biological_process
GO:0001771	immunological synapse for mation	ISS	biological_process
GO:0001954	positive regulation of ce ll-matrix adhesion	IDA	biological_process
GO:0001954	positive regulation of ce ll-matrix adhesion	IDA	biological_process
GO:0002407	dendritic cell chemotaxis	IDA	biological_process
GO:0002548	monocyte chemotaxis	IBA	biological_process
GO:0002606	positive regulation of de ndritic cell antigen proc essing and presentation	ISS	biological_process
GO:0005125	cytokine activity	IEA	molecular_function
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	IEA	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IBA	cellular_component
GO:0005615	extracellular space	IEA	cellular_component
GO:0005622	intracellular	IEA	cellular_component
GO:0006935	chemotaxis	IEA	biological_process
GO:0006954	inflammatory response	IEA	biological_process
GO:0006954	inflammatory response	NAS	biological_process
GO:0006954	inflammatory response	TAS	biological_process
GO:0006955	immune response	IEA	biological_process
GO:0006955	immune response	TAS	biological_process
GO:0007186	G-protein coupled recepto r signaling pathway	IDA	biological_process
GO:0007267	cell-cell signaling	TAS	biological_process
GO:0008009	chemokine activity	IEA	molecular_function
GO:0008009	chemokine activity	IDA	molecular_function
GO:0008009	chemokine activity	IDA	molecular_function
GO:0010560	positive regulation of gl ycoprotein biosynthetic p rocess	ISS	biological_process
GO:0030838	positive regulation of ac tin filament polymerizati on	IDA	biological_process
GO:0031274	positive regulation of ps eudopodium assembly	IDA	biological_process
GO:0031295	T cell costimulation	ISS	biological_process
GO:0031529	ruffle organization	IDA	biological_process
GO:0031732	CCR7 chemokine receptor b inding	IEA	molecular_function
GO:0031732	CCR7 chemokine receptor b inding	ISS	molecular_function
GO:0033630	positive regulation of ce ll adhesion mediated by i ntegrin	IDA	biological_process
GO:0034695	response to prostaglandin E	IDA	biological_process
GO:0035759	mesangial cell-matrix adh esion	IDA	biological_process
GO:0042379	chemokine receptor bindin g	IDA	molecular_function
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological_process
GO:0043552	positive regulation of ph osphatidylinositol 3-kina se activity	IDA	biological_process
GO:0043552	positive regulation of ph osphatidylinositol 3-kina se activity	IDA	biological_process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological_process
GO:0046330	positive regulation of JN K cascade	IDA	biological_process
GO:0048020	CCR chemokine receptor bi nding	IBA	molecular_function
GO:0048247	lymphocyte chemotaxis	IBA	biological_process
GO:0048260	positive regulation of re ceptor-mediated endocytos is	ISS	biological_process
GO:0048469	cell maturation	ISS	biological_process
GO:0050921	positive regulation of ch emotaxis	ISS	biological_process
GO:0051209	release of sequestered ca lcium ion into cytosol	IDA	biological_process
GO:0051491	positive regulation of fi lopodium assembly	IDA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0060326	cell chemotaxis	IEA	biological_process
GO:0060326	cell chemotaxis	IDA	biological_process
GO:0070098	chemokine-mediated signal ing pathway	IBA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0071346	cellular response to inte rferon-gamma	IBA	biological_process
GO:0071347	cellular response to inte rleukin-1	IBA	biological_process
GO:0071356	cellular response to tumo r necrosis factor	IBA	biological_process
GO:0090023	positive regulation of ne utrophil chemotaxis	IDA	biological_process
GO:0090630	activation of GTPase acti vity	IDA	biological_process
GO:0097026	dendritic cell dendrite a ssembly	ISS	biological_process
GO:1903237	negative regulation of le ukocyte tethering or roll ing	IDA	biological_process
GO:2000107	negative regulation of le ukocyte apoptotic process	IDA	biological_process
GO:2000147	positive regulation of ce ll motility	IDA	biological_process
GO:2000406	positive regulation of T cell migration	IDA	biological_process
GO:2000529	positive regulation of my eloid dendritic cell chem otaxis	IDA	biological_process
GO:2000548	negative regulation of de ndritic cell dendrite ass embly	ISS	biological_process
GO:0001768	establishment of T cell p olarity	IDA	biological_process
GO:0001771	immunological synapse for mation	ISS	biological_process
GO:0001954	positive regulation of ce ll-matrix adhesion	IDA	biological_process
GO:0001954	positive regulation of ce ll-matrix adhesion	IDA	biological_process
GO:0002407	dendritic cell chemotaxis	IDA	biological_process
GO:0002548	monocyte chemotaxis	IBA	biological_process
GO:0002606	positive regulation of de ndritic cell antigen proc essing and presentation	ISS	biological_process
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005576	extracellular region	TAS	cellular_component
GO:0005615	extracellular space	IBA	cellular_component
GO:0006954	inflammatory response	NAS	biological_process
GO:0006954	inflammatory response	TAS	biological_process
GO:0006955	immune response	TAS	biological_process
GO:0007186	G-protein coupled recepto r signaling pathway	IDA	biological_process
GO:0007267	cell-cell signaling	TAS	biological_process
GO:0008009	chemokine activity	IDA	molecular_function
GO:0008009	chemokine activity	IDA	molecular_function
GO:0010560	positive regulation of gl ycoprotein biosynthetic p rocess	ISS	biological_process
GO:0030838	positive regulation of ac tin filament polymerizati on	IDA	biological_process
GO:0031274	positive regulation of ps eudopodium assembly	IDA	biological_process
GO:0031295	T cell costimulation	ISS	biological_process
GO:0031529	ruffle organization	IDA	biological_process
GO:0031732	CCR7 chemokine receptor b inding	ISS	molecular_function
GO:0033630	positive regulation of ce ll adhesion mediated by i ntegrin	IDA	biological_process
GO:0034695	response to prostaglandin E	IDA	biological_process
GO:0035759	mesangial cell-matrix adh esion	IDA	biological_process
GO:0042379	chemokine receptor bindin g	IDA	molecular_function
GO:0043123	positive regulation of I- kappaB kinase/NF-kappaB s ignaling	IDA	biological_process
GO:0043552	positive regulation of ph osphatidylinositol 3-kina se activity	IDA	biological_process
GO:0043552	positive regulation of ph osphatidylinositol 3-kina se activity	IDA	biological_process
GO:0045860	positive regulation of pr otein kinase activity	IDA	biological_process
GO:0046330	positive regulation of JN K cascade	IDA	biological_process
GO:0048020	CCR chemokine receptor bi nding	IBA	molecular_function
GO:0048247	lymphocyte chemotaxis	IBA	biological_process
GO:0048260	positive regulation of re ceptor-mediated endocytos is	ISS	biological_process
GO:0048469	cell maturation	ISS	biological_process
GO:0050921	positive regulation of ch emotaxis	ISS	biological_process
GO:0051209	release of sequestered ca lcium ion into cytosol	IDA	biological_process
GO:0051491	positive regulation of fi lopodium assembly	IDA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0051897	positive regulation of pr otein kinase B signaling	IDA	biological_process
GO:0060326	cell chemotaxis	IDA	biological_process
GO:0070098	chemokine-mediated signal ing pathway	IBA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0070374	positive regulation of ER K1 and ERK2 cascade	IDA	biological_process
GO:0071346	cellular response to inte rferon-gamma	IBA	biological_process
GO:0071347	cellular response to inte rleukin-1	IBA	biological_process
GO:0071356	cellular response to tumo r necrosis factor	IBA	biological_process
GO:0090023	positive regulation of ne utrophil chemotaxis	IDA	biological_process
GO:0090630	activation of GTPase acti vity	IDA	biological_process
GO:0097026	dendritic cell dendrite a ssembly	ISS	biological_process
GO:1903237	negative regulation of le ukocyte tethering or roll ing	IDA	biological_process
GO:2000107	negative regulation of le ukocyte apoptotic process	IDA	biological_process
GO:2000147	positive regulation of ce ll motility	IDA	biological_process
GO:2000406	positive regulation of T cell migration	IDA	biological_process
GO:2000529	positive regulation of my eloid dendritic cell chem otaxis	IDA	biological_process
GO:2000548	negative regulation of de ndritic cell dendrite ass embly	ISS	biological_process

KEGG pathways

hsa04060  Cytokine-cytokine receptor interaction
hsa04062  Chemokine signaling pathway
hsa04064  NF-kappa B signaling pathway

Diseases

Associated diseases	References
Endometriosis	PMID: 20797713
Rheumatoid arthritis	PMID: 18794853

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
17506907	Endometrio sis					CCL16 CCL21	Show abstract
20797713	Endometrio sis	CCL21 (rs2812378), HLA-DRB1 (rs660895)	Caucasi an	1,149 samples ( 798 patients wi th endometriosi s and 351 contr ols)	Female infertility		Show abstract