Endometriosis Knowledgebase

Search Result

Gene id

4830

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

NME1 Gene UCSC Ensembl

Aliases

AWD, GAAD, NB, NBS, NDKA, NDPK-A, NDPKA, NM23, NM23-H1

Gene name

NME/NM23 nucleoside diphosphate kinase 1

Alternate names

nucleoside diphosphate kinase A, NDP kinase A, granzyme A-activated DNase, metastasis inhibition factor nm23, non-metastatic cells 1, protein (NM23A) expressed in, tumor metastatic process-associated protein,

Gene location

17q21.33 (51153558: 51162088) Exons: 6 NC_000017.11

Gene summary(Entrez)

This gene (NME1) was identified because of its reduced mRNA transcript levels in highly metastatic cells. Nucleoside diphosphate kinase (NDK) exists as a hexamer composed of 'A' (encoded by this gene) and 'B' (encoded by NME2) isoforms. Mutations in this gene have been identified in aggressive neuroblastomas. Two transcript variants encoding different isoforms have been found for this gene. Co-transcription of this gene and the neighboring downstream gene (NME2) generates naturally-occurring transcripts (NME1-NME2), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Jul 2008]

OMIM

156490

Protein Summary

Protein general information

P15531

Name: Nucleoside diphosphate kinase A (NDK A) (NDP kinase A) (EC 2.7.4.6) (Granzyme A activated DNase) (GAAD) (Metastasis inhibition factor nm23) (NM23 H1) (Tumor metastatic process associated protein)

Length: 152 Mass: 17,149

Tissue specificity: Isoform 1 is expressed in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, spleen and thymus. Expressed in lung carcinoma cell lines but not in normal lung tissues. Isoform 2 is ubiquitously expressed and its expression

Sequence

MANCERTFIAIKPDGVQRGLVGEIIKRFEQKGFRLVGLKFMQASEDLLKEHYVDLKDRPFFAGLVKYMHSGPVVA
MVWEGLNVVKTGRVMLGETNPADSKPGTIRGDFCIQVGRNIIHGSDSVESAEKEIGLWFHPEELVDYTSCAQNWI
YE

Structural information

Interpro:	IPR001564 IPR023005
Prosite:	PS00469
Pfam:	PF00334
PDB:	1JXV 1UCN 2HVD 2HVE 3L7U 4ENO
PDBsum:	1JXV 1UCN 2HVD 2HVE 3L7U 4ENO
DIP:	39164
MINT:	221462
STRING:	ENSP00000013034;

Other Databases

GeneCards: NME1; Malacards: NME1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000287	magnesium ion binding	IDA	molecular_function
GO:0000977	RNA polymerase II regulat ory region sequence-speci fic DNA binding	IEA	molecular_function
GO:0002762	negative regulation of my eloid leukocyte different iation	IEA	biological_process
GO:0003697	single-stranded DNA bindi ng	IEA	molecular_function
GO:0004536	deoxyribonuclease activit y	IDA	molecular_function
GO:0004550	nucleoside diphosphate ki nase activity	EXP	molecular_function
GO:0004550	nucleoside diphosphate ki nase activity	EXP	molecular_function
GO:0004550	nucleoside diphosphate ki nase activity	IDA	molecular_function
GO:0004550	nucleoside diphosphate ki nase activity	EXP	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005524	ATP binding	IDA	molecular_function
GO:0005525	GTP binding	IDA	molecular_function
GO:0005634	nucleus	TAS	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	TAS	cellular_component
GO:0005741	mitochondrial outer membr ane	IEA	cellular_component
GO:0005813	centrosome	IEA	cellular_component
GO:0005829	cytosol	IDA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005882	intermediate filament	IEA	cellular_component
GO:0006163	purine nucleotide metabol ic process	IBA	biological_process
GO:0006165	nucleoside diphosphate ph osphorylation	IEA	biological_process
GO:0006183	GTP biosynthetic process	IEA	biological_process
GO:0006220	pyrimidine nucleotide met abolic process	IBA	biological_process
GO:0006228	UTP biosynthetic process	IEA	biological_process
GO:0006241	CTP biosynthetic process	IEA	biological_process
GO:0006259	DNA metabolic process	IEA	biological_process
GO:0006897	endocytosis	IEA	biological_process
GO:0007595	lactation	IEA	biological_process
GO:0008285	negative regulation of ce ll proliferation	TAS	biological_process
GO:0009142	nucleoside triphosphate b iosynthetic process	IBA	biological_process
GO:0010629	negative regulation of ge ne expression	IEA	biological_process
GO:0010976	positive regulation of ne uron projection developme nt	IEA	biological_process
GO:0014075	response to amine	IEA	biological_process
GO:0015949	nucleobase-containing sma ll molecule interconversi on	TAS	biological_process
GO:0016020	membrane	IDA	cellular_component
GO:0019215	intermediate filament bin ding	IEA	molecular_function
GO:0019901	protein kinase binding	IEA	molecular_function
GO:0021766	hippocampus development	IEA	biological_process
GO:0032587	ruffle membrane	IDA	cellular_component
GO:0033574	response to testosterone	IEA	biological_process
GO:0035690	cellular response to drug	IEA	biological_process
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042981	regulation of apoptotic p rocess	TAS	biological_process
GO:0043015	gamma-tubulin binding	IEA	molecular_function
GO:0043024	ribosomal small subunit b inding	IPI	molecular_function
GO:0043209	myelin sheath	IEA	cellular_component
GO:0043388	positive regulation of DN A binding	IDA	biological_process
GO:0044822	poly(A) RNA binding	IDA	molecular_function
GO:0048471	perinuclear region of cyt oplasm	IEA	cellular_component
GO:0050679	positive regulation of ep ithelial cell proliferati on	IMP	biological_process
GO:0051591	response to cAMP	IEA	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0071333	cellular response to gluc ose stimulus	IEA	biological_process
GO:0071398	cellular response to fatt y acid	IEA	biological_process
GO:0000166	nucleotide binding	IEA	molecular_function
GO:0000287	magnesium ion binding	IDA	molecular_function
GO:0000977	RNA polymerase II regulat ory region sequence-speci fic DNA binding	IEA	molecular_function
GO:0002762	negative regulation of my eloid leukocyte different iation	IEA	biological_process
GO:0003697	single-stranded DNA bindi ng	IEA	molecular_function
GO:0004536	deoxyribonuclease activit y	IDA	molecular_function
GO:0004550	nucleoside diphosphate ki nase activity	IEA	molecular_function
GO:0004550	nucleoside diphosphate ki nase activity	IEA	molecular_function
GO:0004550	nucleoside diphosphate ki nase activity	IEA	molecular_function
GO:0004550	nucleoside diphosphate ki nase activity	EXP	molecular_function
GO:0004550	nucleoside diphosphate ki nase activity	EXP	molecular_function
GO:0004550	nucleoside diphosphate ki nase activity	IDA	molecular_function
GO:0004550	nucleoside diphosphate ki nase activity	EXP	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005524	ATP binding	IEA	molecular_function
GO:0005524	ATP binding	IDA	molecular_function
GO:0005525	GTP binding	IDA	molecular_function
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	TAS	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	TAS	cellular_component
GO:0005739	mitochondrion	IEA	cellular_component
GO:0005741	mitochondrial outer membr ane	IEA	cellular_component
GO:0005813	centrosome	IEA	cellular_component
GO:0005829	cytosol	IEA	cellular_component
GO:0005829	cytosol	IDA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005882	intermediate filament	IEA	cellular_component
GO:0006163	purine nucleotide metabol ic process	IBA	biological_process
GO:0006165	nucleoside diphosphate ph osphorylation	IEA	biological_process
GO:0006165	nucleoside diphosphate ph osphorylation	IEA	biological_process
GO:0006183	GTP biosynthetic process	IEA	biological_process
GO:0006220	pyrimidine nucleotide met abolic process	IBA	biological_process
GO:0006228	UTP biosynthetic process	IEA	biological_process
GO:0006241	CTP biosynthetic process	IEA	biological_process
GO:0006259	DNA metabolic process	IEA	biological_process
GO:0006897	endocytosis	IEA	biological_process
GO:0007399	nervous system developmen t	IEA	biological_process
GO:0007595	lactation	IEA	biological_process
GO:0008285	negative regulation of ce ll proliferation	TAS	biological_process
GO:0009117	nucleotide metabolic proc ess	IEA	biological_process
GO:0009142	nucleoside triphosphate b iosynthetic process	IBA	biological_process
GO:0010629	negative regulation of ge ne expression	IEA	biological_process
GO:0010976	positive regulation of ne uron projection developme nt	IEA	biological_process
GO:0014075	response to amine	IEA	biological_process
GO:0015949	nucleobase-containing sma ll molecule interconversi on	TAS	biological_process
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	IDA	cellular_component
GO:0016301	kinase activity	IEA	molecular_function
GO:0016310	phosphorylation	IEA	biological_process
GO:0016740	transferase activity	IEA	molecular_function
GO:0019215	intermediate filament bin ding	IEA	molecular_function
GO:0019899	enzyme binding	IEA	molecular_function
GO:0019901	protein kinase binding	IEA	molecular_function
GO:0021766	hippocampus development	IEA	biological_process
GO:0030154	cell differentiation	IEA	biological_process
GO:0030879	mammary gland development	IEA	biological_process
GO:0032587	ruffle membrane	IDA	cellular_component
GO:0033574	response to testosterone	IEA	biological_process
GO:0035690	cellular response to drug	IEA	biological_process
GO:0042493	response to drug	IEA	biological_process
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042981	regulation of apoptotic p rocess	TAS	biological_process
GO:0043015	gamma-tubulin binding	IEA	molecular_function
GO:0043024	ribosomal small subunit b inding	IPI	molecular_function
GO:0043209	myelin sheath	IEA	cellular_component
GO:0043388	positive regulation of DN A binding	IDA	biological_process
GO:0044822	poly(A) RNA binding	IDA	molecular_function
GO:0046872	metal ion binding	IEA	molecular_function
GO:0048471	perinuclear region of cyt oplasm	IEA	cellular_component
GO:0050679	positive regulation of ep ithelial cell proliferati on	IMP	biological_process
GO:0051591	response to cAMP	IEA	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0071333	cellular response to gluc ose stimulus	IEA	biological_process
GO:0071398	cellular response to fatt y acid	IEA	biological_process
GO:0000287	magnesium ion binding	IDA	molecular_function
GO:0004536	deoxyribonuclease activit y	IDA	molecular_function
GO:0004550	nucleoside diphosphate ki nase activity	EXP	molecular_function
GO:0004550	nucleoside diphosphate ki nase activity	EXP	molecular_function
GO:0004550	nucleoside diphosphate ki nase activity	IDA	molecular_function
GO:0004550	nucleoside diphosphate ki nase activity	EXP	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005524	ATP binding	IDA	molecular_function
GO:0005525	GTP binding	IDA	molecular_function
GO:0005634	nucleus	TAS	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005634	nucleus	IDA	cellular_component
GO:0005737	cytoplasm	IDA	cellular_component
GO:0005737	cytoplasm	TAS	cellular_component
GO:0005829	cytosol	IDA	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0005829	cytosol	TAS	cellular_component
GO:0006163	purine nucleotide metabol ic process	IBA	biological_process
GO:0006220	pyrimidine nucleotide met abolic process	IBA	biological_process
GO:0008285	negative regulation of ce ll proliferation	TAS	biological_process
GO:0009142	nucleoside triphosphate b iosynthetic process	IBA	biological_process
GO:0015949	nucleobase-containing sma ll molecule interconversi on	TAS	biological_process
GO:0016020	membrane	IDA	cellular_component
GO:0032587	ruffle membrane	IDA	cellular_component
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042802	identical protein binding	IPI	molecular_function
GO:0042981	regulation of apoptotic p rocess	TAS	biological_process
GO:0043024	ribosomal small subunit b inding	IPI	molecular_function
GO:0043388	positive regulation of DN A binding	IDA	biological_process
GO:0044822	poly(A) RNA binding	IDA	molecular_function
GO:0050679	positive regulation of ep ithelial cell proliferati on	IMP	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0070062	extracellular exosome	IDA	cellular_component

KEGG pathways

hsa01100  Metabolic pathways
hsa00230  Purine metabolism
hsa00240  Pyrimidine metabolism

Diseases

Associated diseases	References
Cancer	PMID: 8297127
Endometriosis	PMID: 9458291
Neuroblastoma	OMIM: 156490
Endometriosis	INFBASE24133580

PubMed references

PMID	Condition	Population details	Infertility_type	Associated_genes	Abstract
9458291	Endometrio sis	16 patients wit h histologicall y verified pelv ic endometriosi s		c-myc c-erb-B2 nm23 and p53	Show abstract
24133580	Endometrio sis			NME1 VEGF IL-8	Show abstract
23856325	Endometrio sis		Female infertility		Show abstract