Endometriosis Knowledgebase


A repository for genes associated with endometriosis

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Gene id 4360
Gene Summary        Protein Summary    Gene ontology    KEGG pathways    Diseases    PubMed references    

Gene Summary
Gene Symbol MRC1   Gene   UCSC   Ensembl
Aliases CD206, CLEC13D, CLEC13DL, MMR, MRC1L1, bA541I19.1, hMR
Gene name mannose receptor C-type 1
Alternate names macrophage mannose receptor 1, C-type lectin domain family 13 member D, human mannose receptor, macrophage mannose receptor 1-like protein 1, mannose receptor, C type 1-like 1,
Gene location 10p12.33 (17809342: 17911161)     Exons: 30     NC_000010.11
Gene summary(Entrez) The recognition of complex carbohydrate structures on glycoproteins is an important part of several biological processes, including cell-cell recognition, serum glycoprotein turnover, and neutralization of pathogens. The protein encoded by this gene is a type I membrane receptor that mediates the endocytosis of glycoproteins by macrophages. The protein has been shown to bind high-mannose structures on the surface of potentially pathogenic viruses, bacteria, and fungi so that they can be neutralized by phagocytic engulfment.[provided by RefSeq, Sep 2015]
OMIM 153618

Protein Summary
Protein general information P22897  

Name: Macrophage mannose receptor 1 (MMR) (C-type lectin domain family 13 member D) (C-type lectin domain family 13 member D-like) (Human mannose receptor) (hMR) (Macrophage mannose receptor 1-like protein 1) (CD antigen CD206)

Length: 1456  Mass: 1,66,012

Sequence MRLPLLLVFASVIPGAVLLLDTRQFLIYNEDHKRCVDAVSPSAVQTAACNQDAESQKFRWVSESQIMSVAFKLCL
GVPSKTDWVAITLYACDSKSEFQKWECKNDTLLGIKGEDLFFNYGNRQEKNIMLYKGSGLWSRWKIYGTTDNLCS
RGYEAMYTLLGNANGATCAFPFKFENKWYADCTSAGRSDGWLWCGTTTDYDTDKLFGYCPLKFEGSESLWNKDPL
TSVSYQINSKSALTWHQARKSCQQQNAELLSITEIHEQTYLTGLTSSLTSGLWIGLNSLSFNSGWQWSDRSPFRY
LNWLPGSPSAEPGKSCVSLNPGKNAKWENLECVQKLGYICKKGNTTLNSFVIPSESDVPTHCPSQWWPYAGHCYK
IHRDEKKIQRDALTTCRKEGGDLTSIHTIEELDFIISQLGYEPNDELWIGLNDIKIQMYFEWSDGTPVTFTKWLR
GEPSHENNRQEDCVVMKGKDGYWADRGCEWPLGYICKMKSRSQGPEIVEVEKGCRKGWKKHHFYCYMIGHTLSTF
AEANQTCNNENAYLTTIEDRYEQAFLTSFVGLRPEKYFWTGLSDIQTKGTFQWTIEEEVRFTHWNSDMPGRKPGC
VAMRTGIAGGLWDVLKCDEKAKFVCKHWAEGVTHPPKPTTTPEPKCPEDWGASSRTSLCFKLYAKGKHEKKTWFE
SRDFCRALGGDLASINNKEEQQTIWRLITASGSYHKLFWLGLTYGSPSEGFTWSDGSPVSYENWAYGEPNNYQNV
EYCGELKGDPTMSWNDINCEHLNNWICQIQKGQTPKPEPTPAPQDNPPVTEDGWVIYKDYQYYFSKEKETMDNAR
AFCKRNFGDLVSIQSESEKKFLWKYVNRNDAQSAYFIGLLISLDKKFAWMDGSKVDYVSWATGEPNFANEDENCV
TMYSNSGFWNDINCGYPNAFICQRHNSSINATTVMPTMPSVPSGCKEGWNFYSNKCFKIFGFMEEERKNWQEARK
ACIGFGGNLVSIQNEKEQAFLTYHMKDSTFSAWTGLNDVNSEHTFLWTDGRGVHYTNWGKGYPGGRRSSLSYEDA
DCVVIIGGASNEAGKWMDDTCDSKRGYICQTRSDPSLTNPPATIQTDGFVKYGKSSYSLMRQKFQWHEAETYCKL
HNSLIASILDPYSNAFAWLQMETSNERVWIALNSNLTDNQYTWTDKWRVRYTNWAADEPKLKSACVYLDLDGYWK
TAHCNESFYFLCKRSDEIPATEPPQLPGRCPESDHTAWIPFHGHCYYIESSYTRNWGQASLECLRMGSSLVSIES
AAESSFLSYRVEPLKSKTNFWIGLFRNVEGTWLWINNSPVSFVNWNTGDPSGERNDCVALHASSGFWSNIHCSSY
KGYICKRPKIIDAKPTHELLTTKADTRKMDPSKPSSNVAGVVIIVILLILTGAGLAAYFFYKKRRVHLPQEGAFE
NTLYFNSQSSPGTSDMKDLVGNIEQNEHSVI
Structural information
Protein Domains
 Ricin (22-142)
Fibronectin (163-211)
C-type (225-341)
C-type (369-487)
C-type (511-626)
C-type (655-778)
C-type (807-923)
C-type (952-1080)
C-type (1102-1213)
C-type (1241-1356)
Interpro:  IPR001304 IPR016186 IPR018378 IPR016187 IPR000562 IPR036943 IPR013806 IPR035992 IPR000772
Prosite:   PS00615 PS50041 PS00023 PS51092 PS50231

Pfam:  		 PF00040 PF00059 PF00652
CDD:   cd00062 cd00161

PDB:  		 1EGG 1EGI 5XTS 5XTW
PDBsum:   1EGG 1EGI 5XTS 5XTW

DIP:  		 101
STRING:   ENSP00000239761;
Other Databases GeneCards:  MRC1;  Malacards:  MRC1

Gene ontology


GO accessionTerm nameEvidence codeGo category
GO:0001618 virus receptor activity
 IEA molecular_function
GO:0004872 receptor activity
 IDA molecular_function
GO:0004888 transmembrane signaling r
eceptor activity
 IEA molecular_function
GO:0005515 protein binding
 IPI molecular_function
GO:0005537 mannose binding
 IEA molecular_function
GO:0005886 plasma membrane
 IDA cellular_component
GO:0005887 integral component of pla
sma membrane
 TAS cellular_component
GO:0006898 receptor-mediated endocyt
osis
 IDA biological_process
GO:0007165 signal transduction
 IEA biological_process
GO:0009986 cell surface
 IEA cellular_component
GO:0010008 endosome membrane
 IDA cellular_component
GO:0046718 viral entry into host cel
l
 IEA biological_process
GO:0071222 cellular response to lipo
polysaccharide
 IEA biological_process
GO:0071346 cellular response to inte
rferon-gamma
 IEA biological_process
GO:0071353 cellular response to inte
rleukin-4
 IEA biological_process
GO:0001618 virus receptor activity
 IEA molecular_function
GO:0004872 receptor activity
 IDA molecular_function
GO:0004888 transmembrane signaling r
eceptor activity
 IEA molecular_function
GO:0005515 protein binding
 IPI molecular_function
GO:0005537 mannose binding
 IEA molecular_function
GO:0005537 mannose binding
 TAS molecular_function
GO:0005768 endosome
 IEA cellular_component
GO:0005886 plasma membrane
 IEA cellular_component
GO:0005886 plasma membrane
 IEA cellular_component
GO:0005886 plasma membrane
 IDA cellular_component
GO:0005887 integral component of pla
sma membrane
 TAS cellular_component
GO:0006897 endocytosis
 IEA biological_process
GO:0006898 receptor-mediated endocyt
osis
 IDA biological_process
GO:0007165 signal transduction
 IEA biological_process
GO:0009986 cell surface
 IEA cellular_component
GO:0010008 endosome membrane
 IEA cellular_component
GO:0010008 endosome membrane
 IDA cellular_component
GO:0016020 membrane
 IEA cellular_component
GO:0016021 integral component of mem
brane
 IEA cellular_component
GO:0016032 viral process
 IEA biological_process
GO:0030246 carbohydrate binding
 IEA molecular_function
GO:0046718 viral entry into host cel
l
 IEA biological_process
GO:0071222 cellular response to lipo
polysaccharide
 IEA biological_process
GO:0071346 cellular response to inte
rferon-gamma
 IEA biological_process
GO:0071353 cellular response to inte
rleukin-4
 IEA biological_process
GO:0004872 receptor activity
 IDA molecular_function
GO:0005515 protein binding
 IPI molecular_function
GO:0005537 mannose binding
 TAS molecular_function
GO:0005886 plasma membrane
 IDA cellular_component
GO:0005887 integral component of pla
sma membrane
 TAS cellular_component
GO:0006898 receptor-mediated endocyt
osis
 IDA biological_process
GO:0010008 endosome membrane
 IDA cellular_component

KEGG pathways

hsa05152  Tuberculosis
hsa04145  Phagosome

Diseases

Associated diseases References
Endometriosis INFBASE27793384

PubMed references


PMID Condition Mutation Ethnicity Population details Infertility_type Associated_genes Abstract
27793384 Endometrio
sis
63 (35 patients
with endometri
osis, 28 contro
l women)
Show abstract