Endometriosis Knowledgebase

Search Result

Gene id

3559

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

IL2RA Gene UCSC Ensembl

Aliases

CD25, IDDM10, IL2R, IMD41, TCGFR, p55

Gene name

interleukin 2 receptor subunit alpha

Alternate names

interleukin-2 receptor subunit alpha, IL-2 receptor subunit alpha, IL-2R subunit alpha, TAC antigen, interleukin 2 receptor, alpha,

Gene location

10p15.1 (6062369: 6010693) Exons: 8 NC_000010.11

Gene summary(Entrez)

The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency.[provided by RefSeq, Nov 2009]

OMIM

147730

Protein Summary

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0000165	MAPK cascade	TAS	biological_process
GO:0002437	inflammatory response to antigenic stimulus	IEA	biological_process
GO:0002664	regulation of T cell tole rance induction	IMP	biological_process
GO:0004911	interleukin-2 receptor ac tivity	IEA	molecular_function
GO:0005088	Ras guanyl-nucleotide exc hange factor activity	TAS	molecular_function
GO:0005622	intracellular	IEA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006915	apoptotic process	TAS	biological_process
GO:0006924	activation-induced cell d eath of T cells	IEA	biological_process
GO:0006954	inflammatory response	IBA	biological_process
GO:0006955	immune response	TAS	biological_process
GO:0007166	cell surface receptor sig naling pathway	TAS	biological_process
GO:0007219	Notch signaling pathway	IEA	biological_process
GO:0008144	drug binding	IEA	molecular_function
GO:0008283	cell proliferation	TAS	biological_process
GO:0009897	external side of plasma m embrane	IEA	cellular_component
GO:0016021	integral component of mem brane	IEA	cellular_component
GO:0019976	interleukin-2 binding	IBA	molecular_function
GO:0038110	interleukin-2-mediated si gnaling pathway	IEA	biological_process
GO:0042104	positive regulation of ac tivated T cell proliferat ion	IEA	biological_process
GO:0042130	negative regulation of T cell proliferation	IEA	biological_process
GO:0043547	positive regulation of GT Pase activity	IEA	biological_process
GO:0045582	positive regulation of T cell differentiation	IEA	biological_process
GO:0046013	regulation of T cell home ostatic proliferation	IEA	biological_process
GO:0050687	negative regulation of de fense response to virus	IEA	biological_process
GO:0050728	negative regulation of in flammatory response	IEA	biological_process
GO:0050777	negative regulation of im mune response	IEA	biological_process
GO:0000165	MAPK cascade	TAS	biological_process
GO:0002376	immune system process	IEA	biological_process
GO:0002437	inflammatory response to antigenic stimulus	IEA	biological_process
GO:0002664	regulation of T cell tole rance induction	IMP	biological_process
GO:0004911	interleukin-2 receptor ac tivity	IEA	molecular_function
GO:0004911	interleukin-2 receptor ac tivity	TAS	molecular_function
GO:0005088	Ras guanyl-nucleotide exc hange factor activity	TAS	molecular_function
GO:0005622	intracellular	IEA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006915	apoptotic process	TAS	biological_process
GO:0006924	activation-induced cell d eath of T cells	IEA	biological_process
GO:0006954	inflammatory response	IBA	biological_process
GO:0006955	immune response	TAS	biological_process
GO:0007166	cell surface receptor sig naling pathway	TAS	biological_process
GO:0007219	Notch signaling pathway	IEA	biological_process
GO:0008144	drug binding	IEA	molecular_function
GO:0008283	cell proliferation	TAS	biological_process
GO:0009897	external side of plasma m embrane	IEA	cellular_component
GO:0009986	cell surface	IEA	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016020	membrane	IEA	cellular_component
GO:0016021	integral component of mem brane	IEA	cellular_component
GO:0019976	interleukin-2 binding	IBA	molecular_function
GO:0038110	interleukin-2-mediated si gnaling pathway	IEA	biological_process
GO:0042102	positive regulation of T cell proliferation	IEA	biological_process
GO:0042104	positive regulation of ac tivated T cell proliferat ion	IEA	biological_process
GO:0042130	negative regulation of T cell proliferation	IEA	biological_process
GO:0043029	T cell homeostasis	IEA	biological_process
GO:0043547	positive regulation of GT Pase activity	IEA	biological_process
GO:0045582	positive regulation of T cell differentiation	IEA	biological_process
GO:0046013	regulation of T cell home ostatic proliferation	IEA	biological_process
GO:0050672	negative regulation of ly mphocyte proliferation	IEA	biological_process
GO:0050687	negative regulation of de fense response to virus	IEA	biological_process
GO:0050728	negative regulation of in flammatory response	IEA	biological_process
GO:0050777	negative regulation of im mune response	IEA	biological_process
GO:0000165	MAPK cascade	TAS	biological_process
GO:0002664	regulation of T cell tole rance induction	IMP	biological_process
GO:0004911	interleukin-2 receptor ac tivity	TAS	molecular_function
GO:0005088	Ras guanyl-nucleotide exc hange factor activity	TAS	molecular_function
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0006915	apoptotic process	TAS	biological_process
GO:0006954	inflammatory response	IBA	biological_process
GO:0006955	immune response	TAS	biological_process
GO:0007166	cell surface receptor sig naling pathway	TAS	biological_process
GO:0008283	cell proliferation	TAS	biological_process
GO:0019976	interleukin-2 binding	IBA	molecular_function

KEGG pathways

hsa04151  PI3K-Akt signaling pathway
hsa04060  Cytokine-cytokine receptor interaction
hsa05166  HTLV-I infection
hsa04630  Jak-STAT signaling pathway
hsa04659  Th17 cell differentiation
hsa04144  Endocytosis
hsa05162  Measles
hsa04640  Hematopoietic cell lineage
hsa04658  Th1 and Th2 cell differentiation

Diseases

Associated diseases	References
Addison's disease	PMID: 18593762
Alopecia areata	PMID: 20596022
Alzheimer's disease	PMID: 16385451
Asthenozoospermia	PMID: 8046017
Connective tissue diseases	PMID: 19527514
Crohn's disease	PMID: 21102463
Diabetes	KEGG: H00408, OMIM: 147730
Endometriosis	PMID: 19602517
Graves disease	PMID: 17371467
Implantation failure	PMID: 15105393
Inflammation	PMID: 22228203
Inflammatory bowel disease	PMID: 19471255
Juvenile arthritis	PMID: 19116909
Male infertility	PMID: 9262280
Miscarriage	PMID: 21314851
Multiple sclerosis	PMID: 18354419
Ovarian hyperstimulation syndrome (OHSS)	PMID: 12455193
Pregnancy loss	PMID: 22436290
Reproductive failure	PMID: 23173675
Rheumatoid arthritis	PMID: 20453842
Systemic lupus erythematosus	PMID: 19265545
Unexplained infertility	PMID: 10224804
Unexplained�infertility	PMID: 10224804
Vitiligo	PMID: 20410501

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
11526783	Endometrio sis					HLA-DR CD40 CD25	Show abstract