Endometriosis Knowledgebase

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Gene id

23705

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

CADM1 Gene UCSC Ensembl

Aliases

BL2, IGSF4, IGSF4A, NECL2, Necl-2, RA175, ST17, SYNCAM, TSLC1, sTSLC-1, sgIGSF, synCAM1

Gene name

cell adhesion molecule 1

Alternate names

cell adhesion molecule 1, TSLC-1, TSLC1/Nectin-like 2/IGSF4, immunoglobulin superfamily member 4, immunoglobulin superfamily, member 4D variant 1, immunoglobulin superfamily, member 4D variant 2, nectin-like 2, nectin-like protein 2, spermatogenic immunoglobulin ,

Gene location

11q23.3 (115504522: 115173624) Exons: 16 NC_000011.10

OMIM

605686

Protein Summary

Protein general information

Q9BY67

Name: Cell adhesion molecule 1 (Immunoglobulin superfamily member 4) (IgSF4) (Nectin like protein 2) (NECL 2) (Spermatogenic immunoglobulin superfamily) (SgIgSF) (Synaptic cell adhesion molecule) (SynCAM) (Tumor suppressor in lung cancer 1) (TSLC 1)

Length: 442 Mass: 48,509

Sequence

MASVVLPSGSQCAAAAAAAAPPGLRLRLLLLLFSAAALIPTGDGQNLFTKDVTVIEGEVATISCQVNKSDDSVIQ
LLNPNRQTIYFRDFRPLKDSRFQLLNFSSSELKVSLTNVSISDEGRYFCQLYTDPPQESYTTITVLVPPRNLMID
IQKDTAVEGEEIEVNCTAMASKPATTIRWFKGNTELKGKSEVEEWSDMYTVTSQLMLKVHKEDDGVPVICQVEHP
AVTGNLQTQRYLEVQYKPQVHIQMTYPLQGLTREGDALELTCEAIGKPQPVMVTWVRVDDEMPQHAVLSGPNLFI
NNLNKTDNGTYRCEASNIVGKAHSDYMLYVYDPPTTIPPPTTTTTTTTTTTTTILTIITDSRAGEEGSIRAVDHA
VIGGVVAVVVFAMLCLLIILGRYFARHKGTYFTHEAKGADDAADADTAIINAEGGQNNSEEKKEYFI

Structural information

Protein Domains	Ig-like (45-139) Ig-like (144-238) Ig-like (243-329)
Interpro:	IPR013162 IPR007110 IPR013783 IPR003599 IPR003598 IPR013106 IPR003585
Prosite:	PS50835
Pfam:	PF08205 PF07686
PDB:	3BIN 4H5S
PDBsum:	3BIN 4H5S
DIP:	57599
MINT:	1184987
STRING:	ENSP00000395359;

Other Databases

GeneCards: CADM1; Malacards: CADM1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0004872	receptor activity	IBA	molecular_function
GO:0005102	receptor binding	ISS	molecular_function
GO:0005102	receptor binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005886	plasma membrane	IDA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005887	integral component of pla sma membrane	IBA	cellular_component
GO:0005911	cell-cell junction	ISS	cellular_component
GO:0005913	cell-cell adherens juncti on	IBA	cellular_component
GO:0006915	apoptotic process	IEA	biological_process
GO:0007156	homophilic cell adhesion via plasma membrane adhes ion molecules	IBA	biological_process
GO:0007156	homophilic cell adhesion via plasma membrane adhes ion molecules	ISS	biological_process
GO:0007157	heterophilic cell-cell ad hesion via plasma membran e cell adhesion molecules	IBA	biological_process
GO:0007157	heterophilic cell-cell ad hesion via plasma membran e cell adhesion molecules	ISS	biological_process
GO:0007275	multicellular organism de velopment	IEA	biological_process
GO:0007283	spermatogenesis	IEA	biological_process
GO:0008037	cell recognition	ISS	biological_process
GO:0008037	cell recognition	IDA	biological_process
GO:0016323	basolateral plasma membra ne	ISS	cellular_component
GO:0030154	cell differentiation	IEA	biological_process
GO:0030165	PDZ domain binding	ISS	molecular_function
GO:0034332	adherens junction organiz ation	TAS	biological_process
GO:0042271	susceptibility to natural killer cell mediated cyt otoxicity	ISS	biological_process
GO:0042271	susceptibility to natural killer cell mediated cyt otoxicity	IDA	biological_process
GO:0042803	protein homodimerization activity	IBA	molecular_function
GO:0042803	protein homodimerization activity	ISS	molecular_function
GO:0045202	synapse	IEA	cellular_component
GO:0045954	positive regulation of na tural killer cell mediate d cytotoxicity	ISS	biological_process
GO:0045954	positive regulation of na tural killer cell mediate d cytotoxicity	IDA	biological_process
GO:0050715	positive regulation of cy tokine secretion	IDA	biological_process
GO:0050839	cell adhesion molecule bi nding	IBA	molecular_function
GO:0051606	detection of stimulus	ISS	biological_process
GO:0051606	detection of stimulus	IDA	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0001913	T cell mediated cytotoxic ity	IDA	biological_process
GO:0050798	activated T cell prolifer ation	IDA	biological_process
GO:0002376	immune system process	IEA	biological_process
GO:0004872	receptor activity	IBA	molecular_function
GO:0005102	receptor binding	ISS	molecular_function
GO:0005102	receptor binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	IEA	cellular_component
GO:0005886	plasma membrane	IDA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005887	integral component of pla sma membrane	IBA	cellular_component
GO:0005911	cell-cell junction	ISS	cellular_component
GO:0005913	cell-cell adherens juncti on	IBA	cellular_component
GO:0006915	apoptotic process	IEA	biological_process
GO:0007155	cell adhesion	IEA	biological_process
GO:0007156	homophilic cell adhesion via plasma membrane adhes ion molecules	IBA	biological_process
GO:0007156	homophilic cell adhesion via plasma membrane adhes ion molecules	ISS	biological_process
GO:0007157	heterophilic cell-cell ad hesion via plasma membran e cell adhesion molecules	IBA	biological_process
GO:0007157	heterophilic cell-cell ad hesion via plasma membran e cell adhesion molecules	ISS	biological_process
GO:0007275	multicellular organism de velopment	IEA	biological_process
GO:0007283	spermatogenesis	IEA	biological_process
GO:0008037	cell recognition	ISS	biological_process
GO:0008037	cell recognition	IDA	biological_process
GO:0016020	membrane	IEA	cellular_component
GO:0016021	integral component of mem brane	IEA	cellular_component
GO:0016323	basolateral plasma membra ne	ISS	cellular_component
GO:0030054	cell junction	IEA	cellular_component
GO:0030154	cell differentiation	IEA	biological_process
GO:0030165	PDZ domain binding	ISS	molecular_function
GO:0034332	adherens junction organiz ation	TAS	biological_process
GO:0042271	susceptibility to natural killer cell mediated cyt otoxicity	ISS	biological_process
GO:0042271	susceptibility to natural killer cell mediated cyt otoxicity	IDA	biological_process
GO:0042803	protein homodimerization activity	IBA	molecular_function
GO:0042803	protein homodimerization activity	ISS	molecular_function
GO:0045202	synapse	IEA	cellular_component
GO:0045202	synapse	IEA	cellular_component
GO:0045954	positive regulation of na tural killer cell mediate d cytotoxicity	ISS	biological_process
GO:0045954	positive regulation of na tural killer cell mediate d cytotoxicity	IDA	biological_process
GO:0050715	positive regulation of cy tokine secretion	IDA	biological_process
GO:0050839	cell adhesion molecule bi nding	IBA	molecular_function
GO:0051606	detection of stimulus	ISS	biological_process
GO:0051606	detection of stimulus	IDA	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0001913	T cell mediated cytotoxic ity	IDA	biological_process
GO:0050798	activated T cell prolifer ation	IDA	biological_process
GO:0004872	receptor activity	IBA	molecular_function
GO:0005102	receptor binding	ISS	molecular_function
GO:0005102	receptor binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005886	plasma membrane	IDA	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005886	plasma membrane	TAS	cellular_component
GO:0005887	integral component of pla sma membrane	IBA	cellular_component
GO:0005911	cell-cell junction	ISS	cellular_component
GO:0005913	cell-cell adherens juncti on	IBA	cellular_component
GO:0007156	homophilic cell adhesion via plasma membrane adhes ion molecules	IBA	biological_process
GO:0007156	homophilic cell adhesion via plasma membrane adhes ion molecules	ISS	biological_process
GO:0007157	heterophilic cell-cell ad hesion via plasma membran e cell adhesion molecules	IBA	biological_process
GO:0007157	heterophilic cell-cell ad hesion via plasma membran e cell adhesion molecules	ISS	biological_process
GO:0008037	cell recognition	ISS	biological_process
GO:0008037	cell recognition	IDA	biological_process
GO:0016323	basolateral plasma membra ne	ISS	cellular_component
GO:0030165	PDZ domain binding	ISS	molecular_function
GO:0034332	adherens junction organiz ation	TAS	biological_process
GO:0042271	susceptibility to natural killer cell mediated cyt otoxicity	ISS	biological_process
GO:0042271	susceptibility to natural killer cell mediated cyt otoxicity	IDA	biological_process
GO:0042803	protein homodimerization activity	IBA	molecular_function
GO:0042803	protein homodimerization activity	ISS	molecular_function
GO:0045954	positive regulation of na tural killer cell mediate d cytotoxicity	ISS	biological_process
GO:0045954	positive regulation of na tural killer cell mediate d cytotoxicity	IDA	biological_process
GO:0050715	positive regulation of cy tokine secretion	IDA	biological_process
GO:0050839	cell adhesion molecule bi nding	IBA	molecular_function
GO:0051606	detection of stimulus	ISS	biological_process
GO:0051606	detection of stimulus	IDA	biological_process
GO:0070062	extracellular exosome	IDA	cellular_component
GO:0001913	T cell mediated cytotoxic ity	IDA	biological_process
GO:0050798	activated T cell prolifer ation	IDA	biological_process

KEGG pathways

hsa04514 Cell adhesion molecules

Diseases

Associated diseases	References
Endometriosis	PMID: 22926846
Nasopharyngeal cancer	KEGG: H00054
Endometriosis	INFBASE22926846

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
22926846	Endometrio sis			75 (55 women un dergoing endome trial biopsy or surgery for en dometriosis (20 proliferative endometrium fro m women with en dometriosis, pr oliferative end ometrium from w omen without en dometriosis, 20 peritoneal end ometriosis, 20 ovarian endomet riosis, 20 colo		Nectin-1 -3 -4 and Necl-2	Show abstract