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Gene id

10963

Gene Summary Protein Summary Gene ontology KEGG pathways Diseases PubMed references

Gene Summary

Gene Symbol

STIP1 Gene UCSC Ensembl

Aliases

HEL-S-94n, HOP, IEF-SSP-3521, P60, STI1, STI1L

Gene name

stress induced phosphoprotein 1

Alternate names

stress-induced-phosphoprotein 1, Hsp70/Hsp90-organizing protein, NY-REN-11 antigen, epididymis secretory sperm binding protein Li 94n, hsc70/Hsp90-organizing protein, renal carcinoma antigen NY-REN-11, transformation-sensitive protein IEF SSP 3521,

Gene location

11q13.1 (57335942: 57372398) Exons: 16 NC_000011.10

Gene summary(Entrez)

STIP1 is an adaptor protein that coordinates the functions of HSP70 (see HSPA1A; MIM 140550) and HSP90 (see HSP90AA1; MIM 140571) in protein folding. It is thought to assist in the transfer of proteins from HSP70 to HSP90 by binding both HSP90 and substrate-bound HSP70. STIP1 also stimulates the ATPase activity of HSP70 and inhibits the ATPase activity of HSP90, suggesting that it regulates both the conformations and ATPase cycles of these chaperones (Song and Masison, 2005 [PubMed 16100115]).[supplied by OMIM, Jul 2009]

OMIM

605063

Protein Summary

Protein general information

P31948

Name: Stress-induced-phosphoprotein 1 (STI1) (Hsc70/Hsp90-organizing protein) (Hop) (Renal carcinoma antigen NY-REN-11) (Transformation-sensitive protein IEF SSP 3521)

Length: 543 Mass: 62,639

Sequence

MEQVNELKEKGNKALSVGNIDDALQCYSEAIKLDPHNHVLYSNRSAAYAKKGDYQKAYEDGCKTVDLKPDWGKGY
SRKAAALEFLNRFEEAKRTYEEGLKHEANNPQLKEGLQNMEARLAERKFMNPFNMPNLYQKLESDPRTRTLLSDP
TYRELIEQLRNKPSDLGTKLQDPRIMTTLSVLLGVDLGSMDEEEEIATPPPPPPPKKETKPEPMEEDLPENKKQA
LKEKELGNDAYKKKDFDTALKHYDKAKELDPTNMTYITNQAAVYFEKGDYNKCRELCEKAIEVGRENREDYRQIA
KAYARIGNSYFKEEKYKDAIHFYNKSLAEHRTPDVLKKCQQAEKILKEQERLAYINPDLALEEKNKGNECFQKGD
YPQAMKHYTEAIKRNPKDAKLYSNRAACYTKLLEFQLALKDCEECIQLEPTFIKGYTRKAAALEAMKDYTKAMDV
YQKALDLDSSCKEAADGYQRCMMAQYNRHDSPEDVKRRAMADPEVQQIMSDPAMRLILEQMQKDPQALSEHLKNP
VIAQKIQKLMDVGLIAIR

Structural information

Protein Domains	STI1 (130-169) STI1 (492-531)
Motifs	Bipartite nuclear(222-239)
Interpro:	IPR006636 IPR013026 IPR011990 IPR013105 IPR019734
Prosite:	PS50005 PS50293
Pfam:	PF07719 PF13181
PDB:	1ELR 1ELW 2LNI 2NC9 3ESK 3FWV
PDBsum:	1ELR 1ELW 2LNI 2NC9 3ESK 3FWV
DIP:	41085
MINT:
STRING:	ENSP00000305958;

Other Databases

GeneCards: STIP1; Malacards: STIP1

Gene ontology

GO accession	Term name	Evidence code	Go category
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005634	nucleus	TAS	cellular_component
GO:0005794	Golgi apparatus	TAS	cellular_component
GO:0006950	response to stress	TAS	biological_process
GO:0008022	protein C-terminus bindin g	IEA	molecular_function
GO:0030544	Hsp70 protein binding	IEA	molecular_function
GO:0043209	myelin sheath	IEA	cellular_component
GO:0043234	protein complex	IEA	cellular_component
GO:0044822	poly(A) RNA binding	IDA	molecular_function
GO:0051087	chaperone binding	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	IEA	cellular_component
GO:0005634	nucleus	TAS	cellular_component
GO:0005634	nucleus	TAS	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005737	cytoplasm	IEA	cellular_component
GO:0005794	Golgi apparatus	TAS	cellular_component
GO:0006950	response to stress	TAS	biological_process
GO:0008022	protein C-terminus bindin g	IEA	molecular_function
GO:0030544	Hsp70 protein binding	IEA	molecular_function
GO:0043209	myelin sheath	IEA	cellular_component
GO:0043234	protein complex	IEA	cellular_component
GO:0044822	poly(A) RNA binding	IDA	molecular_function
GO:0051087	chaperone binding	IEA	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005515	protein binding	IPI	molecular_function
GO:0005634	nucleus	TAS	cellular_component
GO:0005634	nucleus	TAS	cellular_component
GO:0005794	Golgi apparatus	TAS	cellular_component
GO:0006950	response to stress	TAS	biological_process
GO:0044822	poly(A) RNA binding	IDA	molecular_function

KEGG pathways

hsa05020 Prion diseases

Diseases

Associated diseases	References
Endometriosis	INFBASE29304094

PubMed references

PMID	Condition	Mutation	Ethnicity	Population details	Infertility_type	Associated_genes	Abstract
29304094	Endometrio sis		Taiwane se			STIP1 MMP9	Show abstract